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High-dose Vitamin D Protocol

The Coimbra Vitamin D Protocol Suppresses Disease Activity In 95% Of Cases

Neurologist Reviews Coimbra Protocol (High Dose Vitamin D3) for Multiple Sclerosis

The Dr. Coimbra vitamin D protocol claims to have successfully suppressed disease activity in about 95% of those M.S. cases treated. Individually tailored doses of vitamin D3 are prescribed by protocol Doctors, who are trained by Dr. Coimbra in application of the protocol. Treatment of Crohns disease has achieved a 100% success rate!

Variability In The Form Of Vd That Is Needed For Specific Situations

  • Use of calcidiol versus calcitriol

    Calcitriol is the most active metabolite of vitamin D. Alfacalcidol is a synthetic calcitriol analogue which is 25-hydroxylated in the liver into calcitriol, avoiding the need for enzymatic conversion by the renal 1alpha-hydroxylase enzyme . Not surprisingly, therefore, alfacalcidol increases calcitriol levels independently of renal function. The effects on intestinal calcium absorption and on bone turnover of oral or parenteral administered calcitriol and alfacalcidol are very similar . In general, the use of 1-alpha-hydroxylated forms is hampered by the higher risk of developing hypercalcemia and/or hypercalciuria . However, the biochemical safety of calcitriol and alfacalcidol is similar. Alfacalcidol has been shown to prevent falls and fractures in women with postmenopausal osteoporosis and also in elderly individuals of both sexes . Some possible differences on vertebral fracture risk between calcitriol and alfacalcidol may be related to the populations enrolled in the trials .

  • When to use active vitamin D analogues versus 25D versus vitamin D-alone or in various combinations

  • Long Term Results Of The Coimbra Vitamin D Protocol

    For many people, things continue to improve long term on the Coimbra vitamin D protocol. Generally, one can expect that one year of M.S. progression will revert to the mobility level before that. So whatever your mobility is one year before beginning the protocol, you can expect the clock to turn back to that date. Some people have enjoyed even more phenomenal results.

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    Reporting Of Suspected Unexpected Serious Adverse Reactions

    A SUSAR needs to be reported to the ethics committee via BASEC and to Swissmedic for category B and C studies within 7 days if the event is fatal, or within 15days .

    The sponsor-investigator must inform all investigators participating in the clinical study of the occurrence of a SUSAR. According to the exact timelines, all in the trial involved ethics committees will be informed about SUSARs in Switzerland via the sponsor-investigator via BASEC.

    Plans For Collection Laboratory Evaluation And Storage Of Biological Specimens For Genetic Or Molecular Analysis In This Trial/future Use

    What is the Dr Coimbra High Dose Vitamin D Protocol?

    We have no plans for collecting, laboratory evaluation, and storage of any biological specimens for genetic or molecular analyses in this trial or further use. This trial only uses blood samples taken routinely during the hospitalization of the patients, and no other samples of any other biological material are planned.

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    The Amount Of Vitamin D To Reach A Desired Level Varies According To The Clinical Conditions

  • Exogenous and endogenous glucocorticoid excess

    A meta-analysis of observational studies has found that most adult subjects administered pharmacological amounts of glucocorticoids had low 25D levels, irrespective of what threshold value was used to define hypovitaminosis D . The bone loss associated with glucocorticoids include distorted PTH pulsatility and pathophysiological perturbations in vitamin D synthesis, metabolism, and action. Interference with vitamin D synthesis occurs at separate steps leading to impaired production of active vitamin D. Vitamin D metabolism, furthermore, is heavily influenced by chronic exposure to either endogenous or exogenous glucocorticoid excess. Glucocorticoids are also associated with target tissue resistance to vitamin D .

    It is, therefore, important to consider vitamin D supplementation when patients are exposed to glucocorticoid excess . Therapeutic goals should take into account two particular points . Resistance to vitamin D dictates a higher level of 25D level to ⥠32 ng/mL. Daily administration of 2,000 IU often will reach and maintain this goal . A second therapeutic point relates to synthetic interference with production of active vitamin D, necessitating in some situations the use of active forms of vitamin D, such as calcidiol or calcitriol .

  • Can Vitamin D Kill You

    • How Vitamin D heals.
    • The real dangers of true high-dose therapy.
    • How to avoid these dangers.
    • What laboratory tests must be done regularly.
    • How to interpret the results of these tests and guarantee any side effects are kept at bay while you reap the benefits.
    • What supplements to take.
    • How each of these supplements relates to vitamin D.
    • How can I know my body is getting its optimal vitamin D dose?
    • How can I keep myself safe while taking this dosage?
    • How can I be sure true high-dose vitamin D therapy actually works?
    • What is the relationship between vitamin D and vitamin K2?
    • How many types of Vitamin K2 there are and how should I supplement them?
  • 15.24 x 2.08 x 22.86 cm
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    • This item: How Not To Die With True High-Dose Vitamin D Therapy: Coimbraâs Protocol and the Secrets of Safe High-Dose Vitamin D3 and Vitamin K2 Supplementation by Tiago Henriques Paperback In Stock.Ships from and sold by

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    Periodic Reporting Of Safety

    An annual safety report is submitted once a year to the local ethics committee by the local investigator and to Swissmedic in case of a category B study, as this study is categorized, via the sponsor-investigator.

    Frequency and plans for auditing trial conduct

    Independently from investigators, regulatory authorities can audit this trial. Study documentation and data are accessible to auditors/inspectors, and questions are answered during inspections. All involved parties must keep the participant data strictly confidential.

    Plans for communicating important protocol amendments to relevant parties

    Substantial amendments are only implemented after approval of the local ethics committee and Swissmedic, respectively.

    Under emergency circumstances, deviations from the protocol to protect human subjects rights, safety, and well-being may proceed without prior approval of the sponsor and the LEC/CA. Such deviations shall be documented and reported to the sponsor and the LEC/CA as soon as possible. All non-substantial amendments are communicated to the CA as soon as possible.

    Dissemination plans

    We aim to publish the results of this study in a peer-reviewed journal. There is no intention to use professional writers. This trial is registered at and and is therefore accessible to the public.

    Reporting Of Safety Signals

    High Dose Vitamin D and Multiple Sclerosis – The Coimbra Protocol

    All suspected new risks and relevant new aspects of known adverse reactions that require safety-related measures, i.e., so-called safety signals, must be reported to the sponsor-investigator within 24h. The sponsor-investigator must report the safety signals within 7 days to the ethics committee via BASEC and to Swissmedic in case of a category B or C study.

    The sponsor-investigator must immediately inform all participating investigators about all safety signals. The other ethics committees involved in the trial will be informed about safety signals in Switzerland via the sponsor-investigator.

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    What Is The Dosage

    The dosage starts at around 1,000 IU per day, per kg of body weight. The dose of vitamin D is then adjusted after two or three months as needed. The dose is adjusted again after a year to compensate for adaptive changes of vitamin D metabolism and a stable level is found. After around two years on vitamin D therapy you will have reached your optimum level of vitamin D.

    Different patients will require different doses of vitamin D and at each appointment the persons parathyroid hormone level will be checked via a blood test to adjust the level of vitamin D. This is measured because vitamin D inhibits the production of PTH. PTH cannot be completely suppressed as it has its own important functions within the body, so PTH levels are kept at their lowest normal limit for each individual.

    Public And Patient Involvement

    No patients were involved in setting the research question or the outcome measure, nor are they involved in developing plans for recruitment, design or implementation of the study. No patients will be asked to advise on interpretation or writing up of results. We will disseminate the results of the research to study participants and the public.

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    How Effective Is The Coimbra Protocol For Treating Ms

    The protocol claims to have successfully suppressed disease activity in about 95% of those MS cases treated. Symptoms of MS fatigue are said to start to decline after one month of starting treatment and may continue to improve. It then takes approximately 79 months to stop MS progression according to Dr Coimbras experience with thousands of patients. Many people with MS claim to have experienced results with the Coimbra Protocol.

    The treatment has to be given by a medical professional who has been trained in the Coimbra Protocol you cant self-treat with this protocol.

    Successful High Dose Vitamin D Should Be Evaluated June 2019

    What is the Dr Coimbra High Dose Vitamin D Protocol? â Vitamin D ...

    Medical Hypotheses, José-Carlos TutorGrupo de Farmacología, Instituto de Investigación Sanitaria , Hospital Clínico Universitario, 15706 Santiago de Compostela, Spain

    For years the successful use of high-dose Vitamin D for Multiple Sclerosis and Autoimmune diseases has been ignored by medical professionals. Perhaps because it requires adjusting the doses for each individual, rather the conventional one-size-dose fits all of Randomized Controlled Trials. Or, perhaps, because too many doctors still falsely believe that > 2,000 IU can be toxic

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    Consequences Of Vitamin D Resistance

    There also is an epigenetic influence of the VDR on genes of the immune system. An in vivo proof-of-principle study investigated chromatin accessibility in monocytes obtained from a human subject before and after a vitamin D bolus dose of 2000 µg . The bolus dose, which raised 25D3 levels by 7.6 ng/ml after two days, resulted in a significant opening or closing of hundreds of gene loci, the most prominent of which belonged to the human leucocyte antigen system coded on chromosome 6. With the help of antigen-presenting proteins of the HLA system, the immune system is able to differentiate between endogenous and exogenous proteins. Therefore, a dysfunction within the HLA system predisposes for the development of autoimmune diseases. Polymorphisms of the HLA system for example constitute the most significant genetic influence on MS . Interestingly, a vitamin D responsive element could be identified at a gene within the HLA-DRB1 region, which is closely associated with the development of MS . Besides the epigenetic influence, this finding also underlines the transcriptional effect of vitamin D on the pathogenesis of this disease.

    In summary, there is much plausibility for acquired vitamin D resistance playing a pathological role in the development of autoimmune diseases, in this way providing an important component for our understanding and explanation of these diseases.

    What Are The Dietary Restrictions For The Coimbra Protocol

    While receiving treatment via the Coimbra Protocol, you need to follow strict dietary restrictions.

    • Vitamin D helps the absorption of calcium so it is important to avoid dairy foods, nuts and seeds as they are high in calcium. Too much calcium in your blood can lead to hypercalcemia which can create kidney stones, weaken your bones and cause problems with how your brain and heart function.

    In addition, the OMS diet strongly recommends that people with MS avoid dairy altogether.

    • You must also drink extra fluids, with a minimum of 2.5 litres of water per day to protect your kidneys by flushing your body and avoid excessive calcium in the body.
    • You must also limit your alcohol intake as otherwise the alcohol can interfere with the vitamin D absorption.

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    Monitoring By A Coimbra Protocol Doctor Is Essential

    A Coimbra vitamin D protocol trained doctor, oversees your care while you follow this treatment. It is an inexpensive option as compared to most other medical treatments when looking at M.S. When I say this I mean VERY reasonable.

    Most doctors are prepared to work with you and are sympathetic and compassionate. These are the comments that I have had from numerous people that have embarked on this protocol. Trained by D. Coimbra, empathy, and a genuine desire to help is their motivation! They have seen first hand how effective this protocol is and how many people have improved.

    An Effective High Dose Supplement Protocol For Hypovitaminosis D

    Dosage For Vitamin D, K2, and Calcium

    In recent years there has been an intense interest in the role ofvitamin D as more clarity emerges on its role in numerousphysiological functions. The recent review by Pearce and Cheetham, 2010 has addressed the clinical and biochemical changes associated withVitD deficiency as well as the population at risk of hypovitaminosis D.The epidemic proportions of VitD insufficiency has encouraged publichealth measures for supplementation, based on the preposition thatrestoration of normal VitD status will be beneficial. Nonetheless, incurrent clinical practice there is a wide variation in treatment targetsfor VitD concentrations as well as VitD supplementation doses andfrequency.

    Recommendations from the Institute of Medicine , for VitDsupplementation suggest 200 IU/d from birth-50 years, 400 IU/d for ages 51-70 years, and 600 IU/d for those > 70 years old . Recent evidenceshow that dietary VitD intake correlates poorly with 25OHD concentrationsand that concentrations can remain marginal deficient despite consumptionof the recommended amount of VitD . In the British National Formulary although a variety of VitD preparations are listed high strengthoral preparations are not readily available in tablet form .

    Table 1: Biochemical results at baseline and at six-month post highdose oral vitamin D supplementation. All results expressed as median. P value was calculated by Mann-Whitney U Test and a p value< 0.05 was considered significant.

    InvestigationBaseline / 6 month follow-up

    75 / 70

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    The Vitamin D Receptor Is Regulated By Multiple Factors

    With first evidence for a VDR in 550 million-year old boneless vertebrates, the VDR is a long-established regulatory protein . From an evolutionary perspective it appears plausible that such a conserved and seminal protein is subject to multiple influencing factors. We elaborate on this using the example of the glucocorticoids in relation to the VDR.

    Glucocorticoids are excreted as part of a stress reaction and ensure the supply of energy needed to solve the problem at hand. Within this context, the inhibition of the VDR appears logical, since it would ensure the shift of energy from the immune to motor systems. However, if the VDR is chronically inhibited, e.g., upon long-term cortisone treatment or chronic stress, this would explain the occurrence of pathological consequences such as osteoporosis. The clinically important immune-suppressive effect of glucocorticoids could be explained in part by the VDR blockade. Also the positive immune modulatory effect of low-dose cortisol treatment could be due to an influence on the VDR.

    Estrogens appear to positively stimulate vitamin D metabolism through a direct effect on the VDR . An activation of the thyroid receptor, on the other hand, can have an inhibitory effect on vitamin D regulation via the VDR . These examples demonstrate that the response of the VDR can be modulated by a variety of physiological influences.

    Special Precautions And Warnings

    When taken by mouthPregnancy and breast-feedingChildrenHardening of the arteries A type of fungal infection called histoplasmosisHigh levels of calcium in the bloodOver-active parathyroid gland LymphomaKidney diseaseA disease that causes swelling in body organs, usually the lungs or lymph nodes Tuberculosis

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    What Is The Dr Coimbra High Dose Vitamin D Protocol

    In this blog post I will attempt to explain the Dr Coimbra protocol in short, as many are looking for information about the Coimbra Protocol but there is so much information where a lot of if is to be found in doctor language which again can be daunting to those who are already sick and need to read this in an easier way.

    Other Supplements Included In Coimbra Protocol

    How Not To Die With True High

    As well as Vitamin D, Dr. Coimbra prescribes a regimen of Vitamins and minerals on the Coimbra vitamin D protocol. It varies slightly from one patient to another, but on the whole, the list contains:

    • vitamin B2
    • folic acid
    • Methyl Folate
    • Selenium
    • CoQ10

    The B2, for instance, is instrumental in helping the body to absorb the Vitamin D.That said 10% to 15% of the worlds population is not able to absorb enough vitamin B2 from regular daily doses. B2 is needed to facilitate the chemical reactions within the body that convert D3 into the active form of vitamin D for immune function 1,25HydroxyD. To see the best deals on vitamins, both price and quality, and to see the supplements that I take on the protocol see: Coimbra Vitamins Best Choices.

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    Vitamin D Metabolism And Assessment Of Vitamin D Status

    Vitamin D is essential for intestinal calcium absorption and for the prevention of rickets or osteomalacia. It also plays in role in calcium, phosphate, and bone metabolism in general besides having multiple extra-skeletal effects .

    Vitamin D is a fat-soluble secosteroid produced by the skin after exposure to sunlight. The photolytic reaction is induced by irradiation of 7-dehydrocholesterol in the skin, by an energetic UV-B wavelength of approximately 280 to 310 nm) .

    UV-B irradiation of 7-dehydrocholesterol promotes a photochemical cleavage between carbons 9-10 of the steroid ring generating the pre-vitamin D3 hormone. Through a time and temperature-dependent molecular isomerization, pre-vitamin D2 is converted to vitamin D3 , as well as to two biologically inert products, tachysterol and luminosterol. Dermal synthesis of vitamin D depends upon the intensity of UV radiation and air pollution .

    The first hydroxylation step at C-25 occurs in the liver by the vitamin D-25-hydroxylase , a mitochondrial cytochrome P450âlike enzyme, converting cholecalciferol into 25D). The half-life of 25 D is approximately 2-3 weeks. The final hydroxylation step occurs in the renal proximal convoluted tubules by the vitamin D-1-hydroxylase , a cytochrome P450âlike oxidase, converting 25D to 1,25-dihydroxycholecalciferol , the active form of vitamin D. The half-life of calcitriol is very short, approximately 6-8 hours.


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