Vitamin D Injection Vs Oral

Who Should Avoid Taking Vitamin D3 Injections

There are several conditions where taking vitamin D could make the condition worse. Those who already have high levels of calcium in their blood should avoid vitamin D, as it may make their condition worse. This is the same for those with hardening of the arteries , those with histoplasmosis , those with hyperparathyroidism , and those with lymphoma . People with kidney disease should also take caution with vitamin D supplementation, as well as people with tuberculosis. Vitamin D supplements may increase calcium levels in these patients and lead to further complications such as kidney stones.

What Is Vitamin D3

Vitamin D is actually a hormone, not a vitamin. Research is still being conducted to determine exactly what vitamin Ds role is in the body and how it affects various symptoms and medical conditions. Vitamin D is involved in numerous metabolic processes and is naturally produced by your body when your skin is exposed to sunlight.

Scientists recommend that people get anywhere from 15 to 30 minutes of sunlight three times a week and suggest that you leave parts of your body uncovered without sunscreen. Sunscreen, especially sunscreens with an SPF over 30, impedes the bodys ability to absorb the sunlight and produce vitamin D. Prolonged exposure to UV rays, however, may be damaging to the skin. Going in the sun for long periods of time can lead to skin cancer, skin aging, heatstroke, and other medical concerns. You should always put on sunscreen if you think you are at risk of sunburn. Other than exposure to sunlight, Vitamin D can also be supplemented through foods, although there arent many foods that are rich in the vitamin. Therefore, several foods are enriched with vitamin D.

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Metabolism And Function Of Vitamin D

The two main forms are vitamin D3 and vitamin D2 . These are transported to the liver and metabolised to 25-hydroxyvitamin D3 and 25-hydroxyvitamin D2 which are the major circulating forms of vitamin D and are measured in most assays. A second hydroxylation takes place in the kidney to form 1,25-dihydroxyvitamin D3, also known as calcitriol, and 1,25-dihydroxyvitamin D2. These are the activated forms of vitamin D and have three main functions:

• enhancing absorption of calcium and phosphate from the small intestine
• inhibiting parathyroid hormone synthesis and secretion
• mineralising the bone matrix.3

Impaired renal function results in reduced production of 1,25-dihydroxyvitamin D, whereas hepatic function, even if it is severely impaired, does not seem to have a major effect on vitamin D metabolism.

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Pharmacokinetic Evaluation Of A Single Intramuscular High Dose Versus An Oral Long

• Contributed equally to this work with: Katharina Wylon, Gennadiy Drozdenko

  Affiliation Klinik für Dermatologie, Venerologie und Allergologie, Charité Universitätsmedizin Berlin, Berlin, Germany

• Contributed equally to this work with: Katharina Wylon, Gennadiy Drozdenko

  Affiliation Klinik für Dermatologie, Venerologie und Allergologie, Charité Universitätsmedizin Berlin, Berlin, Germany

• Affiliation Koordinierungszentrum für Klinische Studien, Charité Universitätsmedizin Berlin, Berlin, Germany

• Affiliation Klinik für Dermatologie, Venerologie und Allergologie, Charité Universitätsmedizin Berlin, Berlin, Germany

• Affiliation Klinik für Dermatologie, Venerologie und Allergologie, Charité Universitätsmedizin Berlin, Berlin, Germany

• Affiliation Klinik für Dermatologie, Venerologie und Allergologie, Charité Universitätsmedizin Berlin, Berlin, Germany

Comparison Of Oral Versus Intramuscular Treatment Of Vitamin D Deficiency Or Insufficiency

1Booali General Hospital, Islamic Azad University, Tehran Medical Branch, Tehran, Iran 2Internal Medicine Ward, Booali General Hospital, Islamic Azad University, Tehran Medical Branch, Tehran, Iran 3Department of Rheumatology, Firouzgar Hospital, Tehran University of Medical Sciences, Tehran, Iran 4Advanced Diagnostic and Interventioanl Radiology Reserach Center, Tehran University of Medical Sciences, Tehran, Iran.

BACKGROUND: Different dosing protocols have been used for vitamin D supplementation, but there has been a lack of comparative data among them. This clinical trial study was aimed to compare the efficacy of two different regimens of vitamin D supplements on serum 25 D3 level, at the end of a 3 months therapy period.

DESIGN: 84 cases of vitamin D deficiency or insufficiency who did not meet exclusion criteria were randomized to two different vitamin D supplementation protocols as pearl 50,000IU weekly for one month then monthly for two months or injection of 300 000IU vitamin D during the 3 months for whom had insufficient level of vitamin D, while the deficient ones were under treatment of pearl 50 000IU weekly for two months and one for another month or injection of 300 000IU vitamin D during the 3 months. The primary outcome measure was the serum 25-hydroxyvitaminD concentration 3 months after onset of treatment.

Note: The correct order of authors and their affiliations is as appears above and not as presented int eh printed version of the abstract book.

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Subject Selection And Study Protocol

This was a prospective, randomized, open-label single institution study in which 40 adults with Vitamin D deficiency were studied. Subjects were otherwise healthy resident doctors, nursing staff, and employees of the hospital without any overt symptoms of Vitamin D deficiency and other metabolic bone diseases who volunteered to be enrolled in the study protocol. Vitamin deficiency was defined as serum 25OHD levels < 30 ng/mL. Recruitment was done in the months of September to November.

Subjects, with any disease, known to affect mineral metabolism were excluded from the study. Subjects with any chronic medical illnesses and chronic drug intake were excluded from the study. Before recruitment, a written informed written consent was taken from the study subjects and the study was approved by the Ethics Committee. Forty subjects with Vitamin D insufficiency/deficiency were recruited.

Twenty subjects selected by simple randomization done in the ratio of 1:1 were given oral cholecalciferol 60,000 IU weekly for 5 weeks, and other 20 were given injection of cholecalciferol 300,000 IU intramuscularly once. Single batch of both the oral and injection cholecalciferol was procured from identical pharmaceutical companies and used for the supplementation.

What Are People Saying Vitamin D3 Injection Reviews

Many people have had great experiences with vitamin D3 injections. After their healthcare provider discovered a deficiency and determined an appropriate dosage, they scheduled a follow-up appointment to ensure the treatment worked. In fact, one patient used vitamin D3 injections and noticed that her levels jumped from 20 to 60 after consistent vitamin D supplementation. One vitamin D3 injection reviewer states they had been struggling with swollen joints, pain, muscle weakness, and was finding it hard to move around before she started taking supplemental vitamin D. After, however, she felt stronger, and her pain decreased significantly. Another patient noted that she was more energetic and was excited that she was no longer dealing with exhaustion.

Unfortunately, vitamin D supplementation is not the right solution for every patient. Some patients report chest tightness, heart-pounding, and feeling weird after taking vitamin D injections. Other side effects that patients who left vitamin D3 injection reviews noticed include shakiness, dizziness, fatigue, and painful cramps in the patients hands, feet, and legs. One user suggested that the uncomfortable symptoms associated with vitamin D may be eased or avoided by taking magnesium alongside vitamin D supplements.

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Research Design And Methods

Up to 8,000 I.U. oral cholecalciferol was administered daily for 84 days in a 4 week dose-escalation setting to vitamin D deficient individuals. In another cohort, a single intramuscular injection of 100,000 I.U. cholecalciferol was given. In both cohorts, individuals without vitamin D intake served as the comparison group. 25-hydroxyvitamin D D) concentrations were measured in all individuals at defined time points throughout the studies.

Difference In Parathyroid Hormone Values Over Time Between Two Groups

Mean PTH levels at baseline in the oral cholecalciferol and IM cholecalciferol group were 52.82 ± 8.51 and 69.92 ± 8.92 pg/mL, respectively . Both oral and IM route led to significant reductions in PTH from baseline at 6 and 12 weeks . Between-group comparison did not show any difference in PTH at 12 weeks between the oral and IM cholecalciferol group . Figure 3 shows the iPTH levels at baseline and during follow-up in oral cholecalciferol and IM cholecalciferol group.

Intact parathyroid hormone levels at baseline and during follow-up in oral cholecalciferol and intramuscular cholecalciferol group

No adverse reaction such as injection site abscess, erythema, or cellulitis was reported during the study in either treatment groups. Serum calcium levels remained within normal limits in all patients at each time point in both studies.

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Vitamin D3 Supplementation In Healthy Adults: A Comparison Between Capsule And Oral Spray Solution As A Method Of Delivery In A Wintertime Randomised Open

Published online by Cambridge University Press: 11 October 2016

Northern Ireland Centre for Food and Health, University of Ulster, Coleraine BT52 1SA, UK

Emeir M. McSorley

Northern Ireland Centre for Food and Health, University of Ulster, Coleraine BT52 1SA, UK

L. Kirsty Pourshahidi

Northern Ireland Centre for Food and Health, University of Ulster, Coleraine BT52 1SA, UK

Sharon M. Madigan

Irish Institute of Sport, Sports Campus Ireland, Dublin 15, Ireland

Eamon Laird

School of Biochemistry and Immunology, Trinity College, Dublin 2, Ireland

Department of Biochemistry, Central Pathology Laboratory, St. Jamess Hospital, Dublin 8, Ireland

Pamela J. Magee*

Northern Ireland Centre for Food and Health, University of Ulster, Coleraine BT52 1SA, UK

*

Oral Vitamin D Supplementation

In the first cohort, 43 healthy subjects between the age of 18 and 60 years were enrolled in an open label study . The exclusion criteria were a lack of consent, incompliance, scheduled sun tanning or UV exposure, a positive history of sarcoidosis, hypercalcemia, serum creatinine concentration > 1 mg/dl, nephrolithiasis, pregnancy and lactation, diseases of the cardiovascular system, cancer, malabsorption or chronic infection. Individuals of the vitamin D group received monthly increasing doses of 2,000 I.U. , 4,000 I.U. and 8,000 I.U. of cholecalciferol per day. Healthy individuals without vitamin D intake served as a control group . Both study groups were comparable with respect to age, gender, and basal serum 25D concentrations . Blood samples for serum analysis were drawn at baseline and after 4, 8 and 12 weeks. Serum 25D levels were measured using the serum 25D ELISA kit .

The study medication was applied by an unblinded staff member to 12 individuals receiving an i.m. injection with 100,000 I.U. cholecalciferol and 6 subjects receiving a sodium chloride injection .

Both study groups were comparable according to age, ethnicity, weight and height . Pharmacokinetics were monitored by 25D serum concentrations which were measured by our laboratory .

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High Dose Oral Versus Intramuscular Vitamin D3 Supplementation In Multiple Sclerosis Patients

• Study Details

Ultraviolet sunlight is too low to produce adequate amounts of vitamin D3, and vitamin D insufficiency lasting 4 to 6 months of the year at latitudes of 42° is common in individuals with low vitamin D intake. Vitamin D has strong immunoregulatory effects, and vitamin D supplementation prevents experimental autoimmune encephalomyelitis , an autoimmune disease in animals that is used as a model of MS.

Recently, emerging data from epidemiologic studies suggest that vitamin D may play an important role in the progression of the development of MS. A longitudinal study in pediatric MS showed a 34% lower risk of relapse for every 10 ng/ml higher 25-hydroxyvitamin D level. A similar magnitude of reduced relapse risk was later reported in an adult MS cohort. Higher vitamin D levels have also been shown to be associated with less subsequent inflammatory MS activity on brain magnetic resonance imaging . Finally, studies have demonstrated that patients have lower vitamin D levels during MS relapses.

Comparing Different Routes Of Vitamin D Administration: A Randomized Interventional Trial

ABSTRACT

Background:

Vitamin D maintains overall good health by boosting up of the immune system through proper function of lungs, heart, muscles, brain and bones. The goal of the study was to determine and compare different routes and formulation of vitamin D3 that was per oral, injectable formulation given orally and intramuscular injection in patients of different groups.

Methods:

This was a randomized clinical trial designed for vitamin D deficient patients. Patients were randomly assigned to three routes of administration i.e. orally, injection formulation given orally andintramuscular injection group. For mild deficiency, 2 doses of 200,000 IU, for moderate deficiency, 3 doses of 200,000 IU and for severe deficiency, 4 doses of 200,000 IU, 25 D was prescribed. Chi-Square test was used to evaluate the significant association .

Results:

A total of 150 patients were enrolled in the study. The mean age ±SD of patients was 48.29 ± 4.65 years. At 4 and 12 weeks after completion of vitamin D3 replacement, levels of 25-hydroxycholecalciferol were measured. In the majority of participants of all three groups, the levels of vitamin D were increased to normal range by week 4 after the final dose of vitamin D3. However, the majority of patients failed to maintain their Vitamin D3 levels within the normal range 12 weeks after the final dose. All three routes of administration of Vitamin D were found equally effective with no significant difference between the routes .

Keywords:

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Vitamin D Deficiency: Symptoms

The most common reason people supplement their vitamin D orally or intramuscularly is that they suffer from a vitamin D deficiency. In most cases, the symptoms of a vitamin D deficiency are quite subtle or even nonexistent. In fact, you may not even realize that you are vitamin D deficient unless your doctor orders a blood test to see what the levels of vitamin D are in your bloodstream. Because vitamin D plays such an important role in your body, several signs and symptoms may indicate you have deficient vitamin D levels.

Potential symptoms of a vitamin D deficiency include:

• Frequent infections
• Slow or impaired wound healing
• Bone loss
• Hair loss

A vitamin D deficiency may look slightly different in children, although a deficiency can still develop at a very young age. In children, symptoms that might indicate a vitamin D deficiency include irritability, lethargy, bone pain or fractures, deformities of the teeth, and developmental delays. It is important to catch a vitamin D deficiency in children before it progresses to something more severe. Severe vitamin D deficiency can lead to more complicated and serious medical conditions, such as rickets.

Vitamin D3 injection reviews can give you an idea of how these symptoms can improve if you choose this form of supplementing your vitamin D3 level.

Blood Collection And Processing

Participants were instructed to fast from 22.00 hours the night before blood sampling and were encouraged to drink water as usual. Blood samples were obtained from the antecubital vein by a trained phlebotomist. Samples were processed within 1 h of collection. Following inversion, serum samples were allowed to clot for up to 60 min, and plasma samples were placed under refrigeration until centrifugation. Tubes were centrifuged at 2200 rpm for 15 min at 4°C. Separated fractions of serum and plasma were then transferred into 0·5-ml aliquots and stored at 80°C until further analysis.

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Compare And Contrast Vitamin D Via Shot And Orally

The National Institutes of Health completed and reported on a research study regarding the overall effectiveness of vitamin D shots and oral applications. The study concluded injections and oral consumption are both effective ways to deliver vitamin D into your body. Although both shots and oral applications are effective means of getting vitamin D into your system, injections edge out oral supplements for what proves to be fairly prevalent problem. The research study reported by the National Institutes of Health found that a large percentage of people who start an oral vitamin D supplement regimen fail to stick to it. Within what often proves to be a short period of time, people begin missing oral doses until they reach a point where they arent taking the oral supplement as all.

Thus, even though oral consumption of vitamin D is an effective delivery system, that regimen oftentimes proves inadequate because people dont remain committed to it. There are some myths associated with vitamin D injections that were addressed in the referenced National Institutes of Health study as well. A prime misconception is that vitamin D injections are costly. In fact, the study revealed that the cost associated with a vitamin D injection oftentimes is less than the expenses of taking oral doses. Another misconception is that a vitamin D shot regimen is time-consuming. In fact, this type of treatment takes a matter of a few minutes when administered by capable, reputable professionals.

Possible Vitamin D Side Effects

The most common reason people experience severe side effects associated with vitamin D is taking excessive amounts. This causes an increase in blood calcium. Some early symptoms that someone is experiencing vitamin D toxicity include nausea, vomiting, diarrhea, constipation, weakness, excessive thirst, an altered level of consciousness, high blood pressure, and kidney failure or hearing loss may also develop

Vitamin D toxicity can be dangerous, and to treat it, your health care provider may recommend avoiding all exposure to the sun, stopping any vitamin D supplements you are taking immediately, and avoiding foods rich in vitamin D. If you experience vitamin D toxicity, it may take a few months for the issue to resolve because the excess vitamin D is stored in fat.

Other possible side effects to be aware of include fatigue and sleepiness, headaches, loss of appetite, a dry mouth, and a metallic taste in the mouth. If you are experiencing side effects connected with your vitamin D injections and the side effects either persist or worsen, you should immediately contact your healthcare provider. If you think you are having an allergic reaction, which may present as swelling of the mouth and throat, rashes, or wheezing and trouble breathing, you should stop the injection therapy immediately and go to an urgent care or emergency room.

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