Typical Dosing For Vitamin D2
- Hypoparathyroidism: The typical dose ranges between 50,000 and 200,000 units by mouth every day with calcium supplementation.
- Vitamin D-resistant rickets: The typical dose ranges between 12,000 and 500,000 units by mouth every day.
- Familial hypophosphatemia: Ask your healthcare provider to see what dose you should take.
Your dose can change depending on your blood vitamin D levels.
Before Taking This Medicine
You should not take ergocalciferol if you have had an allergic reaction to vitamin D, or if you have:
high levels of vitamin D in your body
high levels of calcium in your blood or
any condition that makes it hard for your body to absorb nutrients from food .
Tell your doctor if you have ever had:
kidney disease or
an electrolyte imbalance.
Certain forms of ergocalciferol may contain ingredients you should know about, such as peanut or soybean oil, sugar, aspartame , or certain food dyes. Ask a doctor before using ergocalciferol if you have allergies, diabetes, or phenylketonuria .
Too much vitamin D could harm an unborn baby, and your dose needs may be different during pregnancy. Tell your doctor if you are pregnant or if you become pregnant while taking ergocalciferol.
Ergocalciferol can pass into breast milk and may cause side effects in the nursing baby. Tell your doctor if you are breast-feeding.
Do not give ergocalciferol to a child without medical advice. Your child’s dose will depend on age, weight, diet, and other factors.
How Does Sunlight Give Us Vitamin D
When we get sunlight on our skin, our body produces a substance called cholecalciferol.
This is then turned into calcidiol and then calcitriol by the liver and kidneys.
Calcitriol is what your Doctor would measure to assess your Vitamin D levels.
There are three ways to get enough Vitamin D:
During sunny months, your body might make excess calcidiol. But it will not go to waste. Any extra will be stored in your body fat as a kind of back up for those grey winter days.
Experts think that just 10 minutes of sunlight on your skin is enough to avoid Vitamin D deficiency. So get outside when you can!
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Can You Ever Have Too Much Vitamin D
Yes. You can get too much vitamin D if you overdo the supplements. Interestingly, you cannot get too much vitamin D from the sun. Vitamin D toxicity is, thankfully, quite rare but can lead to hypercalcemia and together the symptoms can include:
- Ataxia .
Do not take higher-than-recommended doses of vitamin D without first discussing it with your doctor. However, your doctor might recommend higher doses of vitamin D if he or she is checking your blood levels and adjusting your dose accordingly. Also, be cautious about getting large doses of vitamin A along with the D in some fish oils. Vitamin A can also reach toxic levels and can cause serious problems.
Comparative Functional Enrichment Analysis Supports Roles For Vitamins D2 And D3 In The Suppression Of Immunity And In Chromatin Modification And Spliceosome Function
As a complementary approach to the functional enrichment analysis of specific subsets of genes whose expression is altered by supplementation with vitamin D2 and D3 but not by placebo treatment, a comparative functional enrichment analysis of all significant changes in each treatment group was performed . This aimed to identify functional categories that are more extensively affected by vitamin D2, or by vitamin D3, or by both vitamins D2 and D3, than by the placebo, and took into consideration the changes occurring in the placebo treatment group across the 12 weeks of the study . Consistent with the earlier analysis, functional categories associated with immunity and immune response pathways are prominent among those genes repressed by vitamin D supplementation , while mitochondrial, ribosomal and spliceosomal functions are prominent in the induced genes . Although the two vitamin treatments share many common categories identified from this analysis, the results also highlight some differences between the respective effects of D2 or D3 supplementation. For example, histone exchange is significant only in the vitamin D2 up-regulated genes, and chromatin modifying enzymes are significant only in the D3 down-regulated genes.
Overall, the observed differences in gene expression from the blood transcriptome presented in this study suggest that the physiological effects of vitamin D3 and D2 may be dissimilar.
How Much Vitamin D Do You Need
In healthy people, the amount of vitamin D needed per day varies by age. The chart below shows the often-cited recommendations of the Institute of Medicine, now the Health and Medicine Division of the National Academies of Sciences, Engineering, and Medicine. It is important to know that these are general recommendations. If your doctor is checking your blood levels, he or she might recommend higher or lower doses based on your individual needs.
If you have osteoporosis, your doctor might suggest a blood test of your vitamin D levels. The amount of vitamin D supplement can be customized for each person, based on the results. For many older patients, a vitamin D supplement containing anywhere between 800 to 2000 IUs daily, which can be obtained without a prescription, can be both safe and beneficial. It is important to speak with your doctor about your individual needs.
|People by age|
*refers to adequate intake vs recommended dietary allowance of the other age groups.
How Much Vitamin D Is Too Much The Surprising Truth
Vitamin D toxicity is rare, but it does occur with extremely high doses.
It usually develops over time, since extra vitamin D can build up in the body.
Nearly all vitamin D overdoses result from taking high amounts of vitamin D supplements.
Its almost impossible to get too much vitamin D from sunlight or food.
This is a detailed article about vitamin D toxicity and how much of it is considered to be too much.
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What To Do If You Miss A Dose Of Vitamin D2
Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.
Oral routeAsk your pharmacist, doctor, or health caregiver about the best way to dispose of any outdated medicine or medicine no longer needed.
Keep all medicine out of the reach of children. Never share your medicine with anyone.
What Happens When You Take Your Daily Vitamin D3
When you take a Vitamin D supplement, the vitamin passes from your bloodstream into your liver.
From here, it goes to the kidneys where it turns into calcitriol.
It is then released back into your bloodstream and can now enter your bodys cells where it attaches to Vitamin D receptors.
At this point, it can get to work regulating the minerals calcium and phosphorous. Clever stuff!
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The Role Of Vitamin D3
Another surprising thing about vitamin D3? Its not actually a vitamin, but a pro-hormone. Its considered a pro-hormone because the body is able to produce it on its own by absorbing sunlight on the skin.
Other vitamins and nutrients are unable to be produced by the body and therefore must be obtained via diet and supplements. The body needs to store a healthy amount of vitamin D in order absorb phosphorous and be able to maintain normal levels of calcium. In fact, vitamin D is essential to many functions in the body:
- Vitamin D is necessary for the maintenance of strong bones and healthy teeth.
- Keeping a healthy store of vitamin D gives added protection to such diseases as cancer, multiple sclerosis, and type 1 diabetes.
- Helps with diabetes management and maintaining healthy insulin levels.
- Vitamin D offers immune support as well as protection to the nervous system and the brain.
- Vitamin D is essential to the health of the lungs and cardiovascular system.
- Helps inhibit the development of cancer.
How Much Vitamin D And Calcium Do You Need
The Endocrine Society and The Institute of Medicine have suggested recommended daily allowances for vitamin D and calcium, as well as maximum daily consumption amounts that you should not exceed for your safety:
The recommendations come with two precautions:
Some people may need more than the RDA if they are:
Taking anticonvulsant medications, glucocorticoids, antifungals such as ketoconazole or medications for AIDS
Taking too much of either nutrient appears to be harmful, with:
Kidney stones associated with too much calcium from supplements
Very high levels of vitamin D potentially causing kidney and tissue damage
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Vitamin D2 Vs D: Whats The Difference
Vitamin D is more than just one vitamin. Its a family of nutrients that shares similarities in chemical structure.
In your diet, the most commonly found members are vitamin D2 and D3. While both types help you meet your vitamin D requirements, they differ in a few important ways.
Research even suggests that vitamin D2 is less effective than vitamin D3 at raising blood levels of vitamin D.
This article sums up the main differences between vitamin D2 and D3.
Vegan Vitamin D Spray
If you want a vegan source of the faster-acting vitamin D3 or simply cannot stand taking tablets or capsules, a vitamin D spray could be for you.
Vitamin D sprays act incredibly fast as they bypass the digestive system and deliver vitamin D directly into the bloodstream.
Beware however, that not all vitamin D sprays are vegan, but BetterYou Dlux Vegan Vitamin D Spray is. Give it a go and see if it works for you.
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How Do You Get Vitamin D And Calcium
Your body makes Vitamin D when your skin is exposed to sun, but several factors limit its creation:
Living anywhere in the country above latitude 33 degrees
Wearing sunscreen to protect against melanoma
Having naturally dark skin
Aging, which changes absorption ability
The amount of sun you would need to achieve normal blood vitamin D levels is probably more than is safe for your skin, so most people may need supplements to achieve a normal vitamin D level.
Either form of vitamin D benefits the body, but very few foods naturally contain the nutrient or are fortified with it. Thats why doctors recommend supplements to make up the difference. Foods containing vitamin D include:
Cod liver oil: 400-1,000 IU per teaspoon
Wild caught salmon: 600-1,000 IU per 3.5 oz
Farmed salmon: 100-250 IU per 3.5 oz
Canned salmon: 300-600 IU per 3.5 oz
Canned sardines: 300 IU per 3.5 oz
Canned mackerel: 250 IU per 3.5 oz
Canned tuna: 236 IU per 3.5 oz
Fresh shitake mushrooms: 100 IU per 3.5 oz
Sundried shitake mushrooms: 1,600 IU per 3.5 oz
Egg yolk: 20 IU per yolk
Milk, orange juice, infant formula, yogurt, margarine, butter, cheese and breakfast cereals are often fortified with vitamin D.
Calcium is found in:
If You Need To Try A Gentle Supplement
If winter is setting in and you really feel as though you need a bit of extra support when it comes to your vitamin D levels, you could try a gentle supplement. As Ive mentioned, our Balance Mineral Drink is a good option but if youre after something stronger you could visit your local health food store to see what is available.
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Advice For Infants And Young Children
The Department of Health and Social Care recommends that babies from birth to 1 year of age should have a daily supplement containing 8.5 to 10 micrograms of vitamin D throughout the year if they are:
- formula-fed and are having less than 500ml of infant formula a day, as infant formula is already fortified with vitamin D
Children aged 1 to 4 years old should be given a daily supplement containing 10 micrograms of vitamin D throughout the year.
You can buy vitamin D supplements or vitamin drops containing vitamin D at most pharmacies and supermarkets.
Women and children who qualify for the Healthy Start scheme can get free supplements containing vitamin D.
See the Healthy Start website for more information.
Weekly And Biweekly Vitamin D2 Prevents Vitamin D Deficiency
- Boston University Medical Center
- Researchers have found that 50,000 International Units of vitamin D2, given weekly for eight weeks, effectively treats vitamin D deficiency.
Boston University School of Medicine researchers have found that 50,000 International Units of vitamin D2, given weekly for eight weeks, effectively treats vitamin D deficiency. Vitamin D2 is a mainstay for the prevention and treatment of vitamin D deficiency in children and adults. Continued treatment with the same dose of vitamin D2 every other week for up to six years after the initial eight-week period prevents vitamin D deficiency from recurring with no toxicity.
The BUSM study appears online in the journal Archives of Internal Medicine.
Vitamin D is essential for strong bones because it helps the body absorb calcium and phosphorus from the food we eat. Vitamin D deficiency can lead to rickets in children and the painful bone disease osteomalacia in adults. Vitamin D deficiency can also cause osteoporosis and has been linked to increased risk of cancer, heart disease, diabetes, autoimmune diseases and infectious diseases including influenza, according to senior author Michael F. Holick, PhD, MD, director of the Bone Healthcare Clinic and the Vitamin D, Skin and Bone Research Laboratory at Boston University School of Medicine.
Quest Diagnostics, the nation’s leading provider of diagnostics testing, information and services, analyzed the specimens used in the study.
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Genotyping Imputation And Quality Control
The full data release contains the cohort of successfully genotyped samples . 49,979 individuals were genotyped using the UK BiLEVE array and 438,398 using the UK Biobank axiom array. Pre-imputation QC, phasing and imputation are described elsewhere. Sample QC included removing individuals of non-European ancestry, high relatedness to others in the sample, or with sex-mismatch. Details of the QC and imputation process has been described previously.
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Vitamin D Can Help Treat Hypertension
According to a 2019 review published in the journal Current Protein & Peptide Science suggests that vitamin D may play a role in treatment of high blood pressureone of the markers of cardiovascular diseasesays Newgent. According to authors of the review, even short-term vitamin D deficiency may directly raise BP and promote target organ damage. The researchers went on to add that, “due to the high correlation between vitamin D and hypertension, vitamin D supplementation therapy may be a new insight in the treatment of hypertension.”
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How Much Vitamin D2 Or Vitamin D3 Should You Take
The recommended minimum daily intake can vary quite a bit from person to person, depending on their age, location, the season, how often their skin is exposed to the sun.Â¹Â³
Guidance around safe upper daily limits varies as well, but generally tops out around 4000 IU per day for most adults.Â¹â´Â¹âµ
But remember, more isnât necessarily better, says Dr. Prassas, nodding to vitamin Dâs current celebrity-vitamin status, which he calls an âoversellâ.
âVitamins have very good PR,â he notes, explaining that while vitamin D is necessary for overall health, and useful for preventing specific conditions such as rickets, thereâs no reason to take more than your doctor recommends.
Weighted Gene Correlation Network Analysis Identifies Modules Of Co
WGCNA quantifies both the correlations between individual pairs of genes or probes across a data set, and also the extent to which these probes share the same neighbours . The WGCNA process creates a dendrogram that clusters similarly abundant probes into discrete branches, and subsequent cutting of the dendrogram yields separate co-expression modules, representing putatively co-regulated sets of genes. The first principal component of the expression matrix of each module defines the expression profile of the eigengene for the module, and this can then be correlated with experimental metadata. By allowing phenotypic traits to be associated with relatively small numbers of module eigengenes, instead of thousands of individual variables , WGCNA both alleviates the multiple testing problem associated with standard differential expression analysis and also directly relates experimental traits to gene expression data in an unsupervised way that is agnostic of the experimental design.
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Can You Have Too Much Vitamin D
Yes, it is possible to overdo vitamin D. What makes vitamin D different from other common vitamin supplements is that its a fat-soluble vitamin. When you ingest too much of a water-soluble vitamin, such as vitamin C, your body will eliminate excess via urine, says Tan. But the same cant be said for vitamin D.
Its very hard to have vitamin D toxicity from sun exposure or diet, but when people start taking supplementswhether through vitamin D drops or a prescriptionit can get to very high levels, says Tan. Too much vitamin D can cause calcium buildup and lead to kidney stones and other problems.
In general, a toxic dose of vitamin D is more than 4,000 IU a daya level that may actually hinder bone health rather than help it, according to a 2019 study in JAMA. In fact, vitamin D toxicity can result in hypercalcemia, a condition marked by an above-average amount of calcium in the blood, which can lead to nausea, vomiting, muscle weakness, neuropsychiatric disturbances, pain, loss of appetite, dehydration, polyuria, excessive thirst and kidney stones.