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What Is The Best Vitamin For Osteoarthritis

Complementary And Alternative Therapies

Supplements for Osteoarthritis: What Should I Know?

Some people with osteoarthritis try complementary or alternative therapies such as acupuncture and aromatherapy and find them helpful.

However, there’s a lack of medical evidence to suggest they’re effective and they generally are not recommended by the National Institute for Health and Care Excellence .

Solgar Boswellia Resin Extract Vegetable Capsules

Solgar Boswellia Resin Extract capsules are great for many reasons, one being they’re nice and inclusive – suitable for vegetarians, vegans and kosher approved.

Boswellia is also known as Indian frankincense, the active components in the extract are widely known for naturally having anti-inflammatory and analgesic properties, it’s also been used to treat a number of inflammatory conditions across the globe for centuries.

Some studies have also shown that it may be able to slow the autoimmune process, thus helping to further prevent cartilage loss, which should allow for more freedom in movement that can be comfortably enjoyed.

Vitamin B Complex Trials For Rheumatoid Arthritis

In this trial, 43 participants with rheumatoid arthritis were randomly allocated to receive 5 mg vitamin B9 with or without 100 mg vitamin B6 once a day for 12 weeks.

  • There was no reported difference in change in the disease activity score or number of painful or swollen joints.
  • Those who received the Vitamin B9 and B6 combination demonstrated significantly greater reductions in some markers of inflammation.
  • No side-effects were recorded.

A trial of low quality. Results of this trial were given a lower weighting when we came to our conclusion about the compound.

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Woman Are More Prone To Problems With Fingers And Knees

Osteoarthritis affects both men and women. However, overall, women are more affected than men, especially with osteoarthritis of the fingers and the knees. Men under age 55 are more likely to have osteoarthritis than women of the same age. After age 55, women are more commonly affected. Researchers believe that because women have broader hips than men, this puts more long-term stress on the knees which means more osteoarthritis.

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Osteoarthritis is a common health condition that may affect almost every joint in your body. It mainly affects the joints, which bear most of your body weight, such as your feet and knees. However, in some cases, the problem may affect the joints, which you use a lot in daily life, like joints of your hands.

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How Does Glucosamine Sulfate Help Osteoarthritis Patients

Glucosamine sulfate functions as the primary building block for formation and repair of cartilage. When taken orally, glucosamine sulfate is absorbed readily into the system. Studies have proven that its as effective as ibuprofen for treating pain of osteoarthritis of the knee after 4 weeks.

More research is needed to understand if it may have the potential to help regenerate cartilage. Glucosamine is especially useful for providing pain relief for some patients with osteoarthritis of the knee, hip and spine.

Glucosamine has unique anti-inflammatory effects and has a protective effect on the cartilage. Studies suggest that glucosamine sulfate may inhibit the breakdown of cartilage associated with osteoarthritis.

A multi-center, randomized study in Germany that followed 252 patients with OA of the knee for 4 weeks reported similar findings. In the study, researchers found that glucosamine sulfate may be a safe and effective symptomatic Slow Acting Drug for OA. Another study that combined evidence from two 3-year studies found that Glucosamine sulfate reduces progression of osteoarthritis in postmenopausal women with knee osteoarthritis. Scientists have found that long-term treatment with glucosamine sulfate retarded the progression of knee osteoarthritis, possibly determining disease modification.

Medium Term Nutraceutical Supplementation In Oa Patients

In the subgroup analysis, the greatest efficacy of nutraceutical supplements on WOMAC index total score and its subscales and also VAS was related to medium term supplementation . Most of these studies involved patients with mild to moderate knee OA according to Kellgren and Lawrence scoring system for classification of knee OA or American College of Rheumatology Classification Criteria for Knee Osteoarthritis which supplements were administered as an adjunctive to symptomatic treatments except nine of them .

Among studies with medium term of supplementation, WOMAC total score was considerably improved through supplementation with CS in patients with mild to moderate knee OA, Deer bone extract in patients with moderate to severe knee OA and PFP and collagen peptides isolated from pork skin in patients with mild to severe knee OA.

The WOMAC all subscale scores were improved through medium term supplementation with A. paniculata purified extract , DBE and MSM . PFP improved only WOMAC pain and physical function subscales in patients with mild to severe knee OA, Boswellia serrata extract improved only WOMAC pain and stiffness subscales score and VAS in patients with mild to moderate knee OA and Artemisia annua extract improved considerably only WOMAC stiffness subscale in knee OA with unknown severity.

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Inclusion And Exclusion Criteria

Inclusion criteria to choose studies for this systematic review and meta-analysis were: RCT a nutraceutical as an intervention either as an adjunctive to standard medicine or as a monotherapy and adults who have been diagnosed with hip or knee OA sufficient data reported about mean changes for Western Ontario and McMaster Universities Arthritis index and/or Visual analogue scale at baseline and at the end of the trial in both intervention and placebo/control groups. Then selected possible clinical trials were excluded based on the exclusion criteria as follows: duplications subjects have other critical diseases such cardiovascular disease, cancer, diabetes, etc. Studies with a short period of followup review articles, semi-experimental studies without a control arm, animal studies, study protocols, letter to editors, case reports, case series, observational studies and unpublished trials.

No language limitations were applied to the search, but only studies published in English or Persian were incorporated because of translation constraints. Trials without full text and those that couldnt attain the minimum quality appraisement score were not included in this systematic review.

Combining Nutritional Supplements With Other Treatments

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Glucosamine and chondroitin sulfate may not provide sufficient pain relief for all osteoarthritis patients. Many patients find it is best to use glucosamine and chondroitin sulfate nutritional supplements in conjunction with other nonsurgical treatments , such as:

Additional non-medical approaches , Graston Technique , muscle energy techniques, proprioceptive neuromuscular rehabilitation , Nimmo method, massage, and others) may also be effective for some patients.

Sometimes rest or weight loss may be recommended for certain patients in order to reduce stress on the joints. Some patients may also require a short period of rest and medication to reduce joint inflammation before they begin to exercise.

The proper course of treatment will differ for each patient and should be supervised by a health professional.

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Mri Or Magnetic Resonance Imaging

This is essentially a more sophisticated way than X-rays of taking a picture of the abnormalities that can occur due to osteoarthritis. You lie on a table that slides inside a tunnel-like area that creates a magnetic field around you. It shows more detail than X-rays, without the radiation risk, but it is more expensive as well.

Because there is no surefire test that diagnosis osteoarthritis, your doctor will use your medical history, physical exam and lab test results to look for indicators of osteoarthritis, including:

Pain, stiffness and limited movement in affected jointsBony enlargement of the affected jointsX-rays that might show formation of bone spursNarrowing of the joint space from cartilage loss shown on an X-ray

Make sure you get the proper information about your diagnosis from your doctor before you leave the office.

This includes basic information about your condition and its management.

Antioxidants And Their Effect On Oa

There are many reasons to include more fruits and veggies in any diet, but for OA sufferers, antioxidants may be the most important reason. Studies have found that a few specific antioxidants vitamin C, vitamin A and vitamin E are particularly helpful when it comes to bone health.

Antioxidants are natural protectors. They fight against compounds known as free radicals that result from the natural process of oxidation within your bodys tissues. These free radicals try to take molecules from other cells, which can damage the very DNA of the cell and set the stage for disease. Since OA involves the breakdown of bone cells and cartilage, better cell protection means slower decay.

There are many naturally-occurring antioxidants, but OA research has focused quite a bit of attention on three common and accessible vitamins:

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Efficacy Of The Intervention


The total score of the WOMAC was evaluated in the 28 articles reviewed. There were 1404 cases in the intervention group and 1360 in the control group. The mean follow-up duration of patients was 17.4 weeks. There was a significant heterogeneity between studies . Based on the meta-analysis results, it was observed that the Pooled Standardized Mean Difference between the intervention and control groups was 0.23 units . Figure shows the forest plot of the combination of results. Results of subgroup analysis according to the supplementation duration showed that the pooled effect size in studies with< 10 months as short term, 1020 months as medium term and> 20 months as long term supplementation duration were 0.05, 0.27 and 0.36, respectively. Figure shows the forest plot of the subgroups by the supplementation duration.

Figure 4

Forest plot presenting the standardized mean difference and 95% confidence interval for the impact of nutraceutical supplementation on WOMAC total score.

Figure 5

Forest plot presenting the impact of nutraceutical supplementation on WOMAC total score .


Figure 6

Forest plot presenting the standardized mean difference and 95% confidence interval for the impact of nutraceutical supplementation on WOMAC pain score.

Figure 7

Forest plot presenting the impact of nutraceutical supplementation on WOMAC pain score .


Figure 8Figure 9

Forest plot presenting the impact of nutraceutical supplementation on WOMAC stiffness score .


Things You Should Know About Dietary Supplements For Osteoarthritis

Alternatives and Supplements for Arthritis Joint Pain ...

Osteoarthritis is the most common type of arthritisâaffecting 27 million Americansâand is an increasing problem among older adults. Treatments for osteoarthritis address the symptoms, such as pain, swelling, and reduced function in the joints. Nonmedicinal approaches involve lifestyle changes such as exercise, weight control, and rest. Conventional medicinal treatments for OA include nonsteroidal anti-inflammatory drugs , acetaminophen , and injections of corticosteroids .

Many people with OA report trying various dietary supplements, including glucosamine and chondroitin, alone or in combination, in an effort to relieve pain and improve function. However, there is no convincing evidence that any dietary supplement helps with OA symptoms or the course of the underlying disease. Here are 6 things you should know about dietary supplements for osteoarthritis:

  • The majority of research has found little effect of glucosamine or chondroitin on symptoms or joint damage associated with osteoarthritis of the knee or hip. Studies have found that glucosamine and chondroitin supplements may interact with the anticoagulant drug warfarin . But overall, studies have not shown any other serious side effects.

  • There is preliminary evidence that avocado/soybean unsaponifiables , supplements made from avocado oil and soybean oil extracts, may have modest beneficial effects on symptoms of osteoarthritis.Safety information has not been sufficiently available.

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    Osteoarthritis And Joint Degeneration

    Osteoarthritis occurs when the cartilage on the ends of the joints wears down and the exposed bones rub together. This degenerative process causes excess friction in the joints, which leads to loss of motion, stiffness and joint pain. Osteoarthritis is more common among middle-aged and older individuals. Symptoms can range from mild to very severe pain in the back, neck, hands, hips, knees, and/or feet.

    When degenerative osteoarthritis occurs in the back, it is usually referred to as facet joint osteoarthritis .

    Glucosamine and chondroitin sulfate are believed to impact the cartilage degeneration process of osteoarthritis in the following ways:

    What Are Glucosamine Sulfate And Chondroitin Sulfate

    Glucosamine sulfate and chondroitin sulfate are components of normal cartilage. These nutritional supplements are available in pharmacies and health food stores without a prescription. They are the building blocks for proteoglycans and appear to stimulate chondrocytes to make new collagen and proteoglycans. The supplements are well-tolerated and safe.

    Because these supplements stimulate the production of new cartilage components, it is thought that they may be able to help the body repair cartilage damaged by osteoarthritis. However, much of the research on glucosamine sulfate and chondroitin sulfate has been done in vitro and in animals. To date, there has not been any convincing proof in humans that glucosamine and chondroitin sulfates can help rebuild cartilage or prevent damage to cartilage.

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    Signs And Symptoms Of Osteoarthritis

    • Swelling and tenderness. Joints may swell, feel warm to the touch, and hurt when pressed.
    • Often, joint pain is the first tell-tale of arthritis. Pain may be aching, dull, throbbing, or shooting. People may also feel a grating sensation, due to the bones of the affected joint making contact.
    • Reduced flexibility. A persons range of movement will become restricted.
    • Stiffness in the joints is common in osteoarthritis

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  • Curcumin Evidence suggests the turmeric root has anti-inflammatory properties.
  • Vitamin D. If you have arthritis pain or are at high risk for arthritis, your doctor may recommend a vitamin D supplement.
  • Omega-3 fatty acids.
  • Glucosamine and chondroitin sulfate.
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    Glucosamine Hcl & Chondroitin Tablets

    If you’re not ready to give up activity just yet, it’s good practice to replenish what you’re losing.

    Our bodies naturally create glucosamine and chondroitin, they’re what form all of the cartilage components, cartilage absorption in the early stage of arthritis is what you’ll want to repair and rejuvenate in order to comfortably move around.

    If you’re running, doing intense training or any activities that might need a little bit of absorption on impact.

    Short Term Nutraceutical Supplementation In Oa Patients

    In studies with short term duration of supplementation, significant effects of nutraceutical supplement only were seen on VAS and WOMAC stiffness scores. Among these, three supplements had significant effects on VAS pain intensity. Low dose Sierrasil in addition to cat’s claw extract and l-carnitine had a considerable effect also on WOMAC all subscales in patients with mild to moderate knee OA. Additionally, milk protein concentrate showed significant effects on WOMAC stiffness score in knee OA patients with unspecified disease severity and Chicken comb extract with a high content of hyaluronic acid had a considerable effect on WOMAC total score, in patients with mild to severe knee OA according to Kellgren and Lawrence scoring system for classification of knee OA.

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    Overweight And Obese People

    In a 2008 study which suggested that nearly 1 in 2 people will develop knee osteoarthritis before they turn 85, researchers found that the risk rose to 2 in 3 for people who were overweight or obese. Although race and sex seemed to have no effect on the risk of getting knee osteoarthritis, the study found that the chances went up significantly with increasing body weight. Those who stayed at a normal weight throughout their lives had the lowest lifetime risk of any group in the study 30 percent. Those whose weight fluctuated from normal to overweight/obese had the highest lifetime risk of knee osteoarthritis 60 percent.

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    In this 2019 study reported by the US National Library of Medicine these were the findings.

    Based on results of this study that was conducted in Sanandaj, the center of Kurdistan province in Iran, living in highland areas, using regular toilet, having history of knee injury and lower limb fracture, higher BMI, using high-heeled shoes in the past, having pain and swelling in past years and increasing in the number of pregnancies were recognized as risk factors for knee osteoarthritis.

    Data Synthesis And Analysis

    Glucosamine and Chondroitin for Osteoarthritis

    Data were pooled using random-effects model. As the included trials used different scales to assess the same outcome, standardised mean differences were calculated for continuous data, and risk ratios were used for dichotomous data with their 95% CIs. To facilitate interpretation of estimated treatment effects, we considered ES up to 0.3 as small, between 0.3 and 0.8 as moderate, and greater than 0.8 as large effects. A threshold of 0.37 standardised units was defined as the minimum clinically important difference , which was based on the median MCID found in recent studies in patients with OA. We considered the effects as clinically important if ES and 95%CI exceeded our prespecified MCID threshold of 0.37. The effects were considered unclear if clinically important when the 95%CI crossed this threshold, and statistically significant but clearly not clinically important when the 95%CI was below the MCID but above the null effect line. If the 95%CI crossed the null effect line, supplements were considered ineffective.

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    Role Of Vitamin E In Osteoarthritis

    Vitamin E is an excellent agent to treat or avoid osteoarthritis because of its anti-inflammatory and antioxidant properties. Key facts are-

    • Cellular studies conducted on Vitamin E revealed that vitamin E mitigated type of oxidative stress in chondrocyte culture or cartilage explants invoked by free radicals or mechanical stress.
    • Animal studies proved that treatment via Vitamin E avoided degeneration in cartilage and improved oxidative status in various osteoarthritis animal models.
    • Synovial or low circulating types of Vitamin E were present in patients suffering from osteoarthritis.
    • Observational studies proved that Vitamin E has a relationship in managing the progression of osteoarthritis in people.

    In simple words, Vitamin E retards the progression of underlying symptoms of osteoarthritis by simply ameliorating oxidative stress and the pain or inflammation of joints.


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