Is Vitamin D Or D3 More Effective
Vitamin D2 and D3 are absorbed into the bloodstream where they are metabolized by the liver into 25-hydroxyvitamin D2 and 25-hydroxyvitamin D3, otherwise collectively known as 25D or calcifediol. Calcifediol is the vitamin D complex circulating in your blood, and its levels directly reflect your bodys stores of vitamin D. Calcifediol is commonly referred to as the active form of vitamin D. When your doctor orders lab tests to check your vitamin D levels, they are measuring your calcifediol levels.
There have been several studies comparing whether supplementation with vitamin D2 or D3 produces a higher blood level of calcifediol. A study published by the National Institutes of Health was conducted in elderly, post-menopausal women who had been identified as vitamin D deficient. It compared the effects of receiving a single high dose of vitamin D2 or vitamin D3 on calcifediol levels. The study concluded that vitamin D3 produced about twice the amount of circulating calcifediol in this patient population versus that of vitamin D2.
In a separate clinical trial comparing a 10-week regimen of twice weekly 50,000 IU dosing of both vitamin D2 and vitamin D3 in demographically matched groups, vitamin D3 was also found to be superior in producing higher levels of 25D, or calcifediol.
A Stronger Immune System
The human bodys immune system plays an important part in its ability to fight off viruses and disease-causing bacteria, as well as infections. When the immune system is weak, a person is more likely to become sick and develop the disease. A stronger immune system, however, helps to prevent the frequent occurrence of illness. A review paper published by the Feinstein Institute for Medical Research explains that the cells of the immune system contains vitamin D receptors. The particular cells that contain these receptors include antigen-presenting cells, T cells, and B cells. This means that vitamin D is able to assist with the action of the immune system and, according to the review paper, may also help to reduce the risk of obtaining an infection.
Can You Get Too Much Vitamin D
Vitamin D’s role in calcium absorption and homeostasis in the body is one essential function of the fat-soluble nutrient.* “Vitamin D increases calcium absorption in the gastrointestinal tract,” says Sina Gallo, Ph.D., RDN, a nutritional sciences professor at the University of Georgia.
At very high vitamin D doses , “this helpful vitamin D/calcium relationship can tip from normal to not-so-normal, and too much calcium can contribute to kidney stones and blood vessel issues,” Ferira explains.
In rare cases, this calcium buildup can cause soft tissues throughout your body to harden, which can cause severe concerns. That’s why “vitamin D research studies measure calcium levels in the blood and urine,” Ferira says, “to ensure the healthy balance doesn’t tip to unhealthy, which is very rare in healthy individuals receiving normal doses of vitamin D.”
So why the conservative messaging? “Public health guidance, such as that coming from the Institute of Medicine , needs to be conservative to balance the risk of toxicity in a population,” adds Gallo. “A number of other factors affect vitamin D status, including endogenous production , adiposity, age, latitude, age, etc., which makes one recommendation for all individuals difficult.” A fair reason, but lo and behold, you are an individual and the research is evolvingand we are seeing a slight shift in perspective.
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What Is Vitamin D And Why Is It Important
Vitamin D belongs to the family of fat-soluble vitamins, which include vitamins A, D, E and K. These vitamins are absorbed well with fat and are stored in the liver and fatty tissues.
There are two main forms of vitamin D in the diet:
- Vitamin D2 : Found in plant foods like mushrooms.
- Vitamin D3 : Found in animal foods like salmon, cod and egg yolks.
However, sunlight is the best natural source of vitamin D3. The UV rays from sunlight convert cholesterol in your skin into vitamin D3 .
Before your body can use dietary vitamin D, it must be activated through a series of steps .
First, the liver converts dietary vitamin D into the storage form of vitamin D. This is the form that is measured in blood tests. Later, the storage form is converted by the kidneys to the active form of vitamin D thats used by the body .
Interestingly, D3 is twice as effective at raising blood levels of vitamin D as vitamin D2 .
The main role of vitamin D in the body is to manage blood levels of calcium and phosphorus. These minerals are important for healthy bones .
Research also shows that vitamin D aids your immune system and may reduce your risk of heart disease and certain cancers .
A low blood level of vitamin D is linked to a greater risk of fractures and falls, heart disease, multiple sclerosis, several cancers and even death (
For instance, an analysis of five studies examined the link between vitamin D blood levels and colorectal cancer .
Drug Interactions Of Vitamin D2 Vs D3
Vitamin D2 and D3 each are metabolized by the liver to 25D, and therefore the potential drug interactions are similar for both forms. Vitamin D may increase the serum levels of aluminum when taken with aluminum hydroxide, a common antacid, and therefore the combination should be avoided. Thiazide diuretics, such as hydrochlorothiazide, may increase the chance of vitamin D raising calcium levels in the blood to a dangerously high level. Patients on both thiazide diuretics and vitamin D supplementation should be monitored for this effect by their healthcare provider. Some drugs may decrease the absorption and effectiveness of your vitamin D supplement. Bile-acid sequestrants, such as cholestyramine, are an example of a drug which will impair vitamin D absorption. Vitamin D and cholestyramine should not be administered at the same time.
The following table may not be a complete list of drug interactions. Please consult your pharmacist or healthcare provider for more information and a complete list of interactions.
Who Should Take Vitamin D3 5000 Iu
Vitamin D3 is essential for people of all ages, but it is especially important for seniors. Vitamin D3 5000 IU helps to prevent falls and fractures by maintaining muscle strength and improving balance.
It also strengthens the immune system and protects against some chronic diseases, such as heart disease, cancer, and diabetes. If you are over the age of 60, have dark skin, or do not get much sun exposure, you may need to take a higher dose of vitamin D.
Ask your doctor if you should take a supplement. If you find that your doctor says you need to take a d3 supplement, consider taking Elm & Rye.
What Are The Health Effects Of Vitamin D
Bone disordersAs we age, millions of people develop or are at risk of developing osteoporosis. Once onset, the bones become weaker and may fall due to a fall. Osteoporosis results from long-term inadequate intake of calcium and vitamin D. Taken together with vitamin D3 and calcium supplements have been shown to reduce bone loss and fracture risk in elderly people aged 62 to 85 years I am. Talk to your healthcare professionals about the amount of vitamin D that both men and women should take as part of their osteoporosis prevention and treatment plan.
CancerSeveral studies have suggested that vitamin D may also prevent colorectal cancer and possibly prostate and breast cancer. However, it has been pointed out that the higher the vitamin D concentration in the blood, the higher the incidence of pancreatic cancer. It is too early to say if low vitamin D status increases cancer risk, or does high vitamin D status prevent cancer, or, conversely, increase cancer risk in some people? It is the current situation.
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What Does D3 5000 Iu Mean
IU stands for International Unit and is a measure that is used in pharmacy and for the use of measurement of vitamins. … D3, the conversion is 1 I.U. = . 025 mcg cholecalciferol . So, 5000 I.U.’s of cholecalciferol equals 125 mcg of the Vit D3 substance which is precisely what the bottle says it contains.
Why Is Vitamin D Important
Also called the sunshine vitamin, this nutrient is critical for building strong bones and maintaining a healthy immune system. Deficiency in this vitamin has been linked to depression, muscle weakness, high blood pressure, and the risk of certain cancers. Especially in areas of the country that regularly have overcast weather, vitamin D deficiency can be a common problem.
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Vitamin D Deficiency And Thyroid Disease
There’s increasing evidence to suggest that low levels of vitamin D may play a role in thyroid disorders. For instance, research has suggested a possible link between vitamin D deficiency and autoimmune thyroid disorders, namely Hashimoto’s thyroiditis, the most common cause of hypothyroidism , and Grave’s disease, characterized by an overactive thyroid.
In one study, 72% of subjects with autoimmune thyroid disease were deficient in vitamin D, whereas just under 31% of healthy subjects had low levels of vitamin D. Similarly, a study of people in Greece with Hashimoto’s thyroiditis revealed that more than 85% of them had low levels of vitamin D, as well as high levels of anti-thyroid antibodies.
Vitamin D supplementation also has shown promise as a way to help treat thyroid disease. In the same Greek study, for example, the Hashimoto thyroiditis patients who were deficient in vitamin D took 1,200 to 4,000 international units of vitamin D every day for four months, after which time they had significantly lower levels of anti-thyroid antibodies.
In yet another study, people with hypothyroidism who took extra vitamin D supplements for 12 weeks had improvements in blood levels of thyroid stimulating hormone .
Aleksandra Jankovic / Stocksy United
How Should I Take Cholecalciferol
Follow all directions on your prescription label and read all medication guides or instruction sheets. Use only the recommended dose of cholecalciferol.
It may be best to take cholecalciferol after a meal, but you may take this medicine with or without food.
Measure liquid medicine carefully. Use the dosing syringe provided, or use a medicine dose-measuring device .
The chewable tablet must be chewed before you swallow it.
To take a disintegrating tablet, place it on your tongue and do not swallow the tablet whole. Allow it to dissolve in your mouth without chewing. If desired, you may drink liquid to help swallow the dissolved tablet.
The cholecalciferol wafer is usually taken only once per week or once per month. Follow your doctor’s dosing instructions very carefully. The wafer must be chewed before you swallow it.
While using cholecalciferol, you will need frequent blood tests. You may also need x-rays.
Your doctor will determine how long to treat you with this medicine.
Cholecalciferol may be only part of a complete program of treatment that also includes dietary changes and taking calcium and vitamin supplements. Follow your doctor’s instructions very closely.
Learn about the foods you should eat to make sure you get enough calcium and vitamin D in your diet. Your cholecalciferol dose may need to be adjusted as you make changes to your diet.
Store at room temperature away from moisture, light, and heat.
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Buying Guide For Best Vitamin D Supplements
A walk outdoors on a sunny day isnt just a good way to lift your spirits, it also increases your bodys stores of vitamin D, the vitamin your body produces from exposure to the sun. However, for a variety of reasons, many people are deficient in this crucial vitamin, which plays an important role in the strength and health of your bones and teeth, among other benefits.
If you think you might not be getting enough vitamin D or blood tests have revealed a deficiency youve probably perused the many brands and formulas of vitamin D supplements on the market. With so many options to choose from, it can be a bit overwhelming separating the marketing hype from reality.
Luckily, at BestReviews, you can easily find the best products for you with our top recommendations and information-filled shopping guides. For everything you need to know about vitamin D supplements before you buy, just keep reading.
Do I Need To Take A Vitamin D3 5000 Iu Supplement
If you don’t get enough vitamin D from sunlight or your food, you may need to take a supplement. Vitamin D tablets and liquid supplements are available in capsule, gummy, and liquid forms. Before taking any pills, consult your doctor since they can affect other medicines you’re taking.
The benefits of taking a vitamin D3 5000 IU supplement are that it can help improve bone health, support the immune system, and promote cardiovascular health. Vitamin D is important for overall health, and many people don’t get enough of it from the sun or their diet.
If you’re wondering whether you should take a vitamin D supplement, the short answer is that it depends. Vitamin D is an important vitamin for overall health, but many people don’t get enough from the sun or their diet. If you’re at risk for vitamin D deficiency, talk to your doctor about whether a supplement is right for you.
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What Is Vitamin D3 5000
Vitamin D3 5000 IU is a high-dose supplement that can help treat vitamin D deficiency, which occurs when people dont get enough vitamin D through the sun or their diet. Studies have shown that vitamin D3 5000 IU can also improve blood glucose levels and reduce blood pressure. In addition, there is little or no risk of kidney damage and a moderate risk of side effects. Medical experts say that it may even offer some benefits for people with diabetes. Vitamin D and Risks Because of its powerful antioxidant properties, vitamin D is called a vitamin rather than a mineral. Because of the possibility of cancer and heart disease, however, doctors recommend that people get a vitamin D test in addition to checking their blood sugar and blood pressure.
What Is The Best Time To Take Vitamin D3 5000 Iu
Many individuals prefer to start the day with vitamin D supplements. Not only is it more convenient, but taking vitamins in the morning is easier than later in the day. If you have trouble remembering to take your vitamin D supplement, try setting an alarm on your phone or keeping the bottle in a visible spot.
Save Quotation To File
Deficiency is strongly linked to elevated threat for a mess of ailments, a number of of which have traditionally been proven to enhance dramatically with both sufficient UVB publicity to the pores and skin, or to oral or topical supplementation with vitamin D. These ailments embrace bronchial asthma, psoriasis, rheumatoid arthritis, rickets and tuberculosis. Throughout this time, weve admitted over 4700 sufferers, the overwhelming majority of whom agreed to supplementation with both 5000 or 10,000 IUs/day. Because of illness considerations, a number of agreed to bigger quantities, starting from 20,000 to 50,000 IUs/day. There have been no circumstances of vitamin D3 induced hypercalcemia or any antagonistic occasions attributable to vitamin D3 supplementation in any affected person. Three sufferers with psoriasis confirmed marked medical enchancment of their pores and skin utilizing 20,000 to 50,000 IUs/day. In abstract, long-term supplementation with vitamin D3 in doses starting from 5000 to 50,000 IUs/day seems to be saf.
Before Taking This Medicine
You should not use cholecalciferol if you have had an allergic reaction to vitamin D, or if you have:
high levels of vitamin D in your body
high levels of calcium in your blood or
any condition that makes it hard for your body to absorb nutrients from food .
Tell your doctor if you have ever had:
kidney disease or
an electrolyte imbalance.
Certain forms of cholecalciferol may contain ingredients you should know about, such as peanut or soybean oil, sugar, aspartame , or certain food dyes. Ask a doctor before using cholecalciferol if you have allergies, diabetes, or phenylketonuria .
Too much vitamin D could harm an unborn baby or a nursing baby. Ask a doctor before using Vitamin D3 if you are pregnant or breast-feeding. Your dose needs may be different during pregnancy or while you are nursing.
Do not give cholecalciferol to a child without medical advice. Your child’s dose will depend on age, weight, diet, and other factors.
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Might Prevent Certain Types Of Cancer
Vitamin D3 can assist decrease the chance of developing particular types of cancer. Epidemiological studies have shown that people who reside in southern/equatorial regions and are more exposed to the sun have a lower risk of some malignancies.
Vitamin D has been linked to cancer in numerous studies. Vitamin D aids in the repair and regeneration of cells, which might slow the growth of cancerous tumors, stimulate the death of cells that have been damaged by cancer, and decrease blood vessel formation in tumors.
Can Increase Metabolism And Promote Weight Loss
Large amounts of vitamin D can help boost your metabolism so you are able to lose weight easier, say Murray and Hoffman. Dowd and Stafford add that sufficient intake of vitamin D can help you exercise more effectively and can help increase the overall strength of your muscles 1. Vitamin D also works to help your body maintain muscle mass, making it easier for you to increase the intensity of your workouts if you want to shed pounds. As you get stronger, your body will be able to retain and use vitamin D more efficiently, which will help improve all aspects of your health, say Dowd and Stafford 1. You may benefit from doses as high as 5000 IU if you are significantly overweight or if other weight loss approaches have not worked for you.
- Large amounts of vitamin D can help boost your metabolism so you are able to lose weight easier, say Murray and Hoffman.
- Dowd and Stafford add that sufficient intake of vitamin D can help you exercise more effectively and can help increase the overall strength of your muscles 1.
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