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Hmb Supplement And Vitamin D

Hmb And Vitamin D: Whats The Connection

Should You Supplement HMB?

Pairing other vitamins has the potential to enhance their biological activities. For example, vitamin D is needed to support the role of calcium in bone health vitamin C can help regenerate vitamin E to support antioxidant activity.

But where HMB is concerned, adding in the sunshine vitamin may brighten up its role in muscle growth and preservation.

Theres no denying that HMB offers some great benefits for muscle mass, strength, function, and protein kinetics, but the extent of those benefits may be dependent on circulating levels of vitamin D 8.

Heres some of the research to prove it.

  • A 2020 study published in the Journal of Gerontology Medicine Sciences looked at the effect of HMB supplementation combined with vitamin D on muscle strength in adults over 60 with low vitamin D status 9. Results found HMB+D3 supplementation offered significant benefits for lean body mass in the non-exercise group at six months. They concluded that HMB+D3 supplementation may enhance muscle strength and physical functionality in older adults regardless of exercise regimens.
  • A 2016 study published in Nutrition in Clinical Practice investigated the effects of calcium, HMB, vitamin D, and protein supplementation on wound healing, immobilization period, muscle strength, and laboratory parameters in older adults with hip fractures 10. Researchers found that the combination accelerated wound healing, reduced immobilization period, and increased muscle strength without altering BMI.

Hmb Plus D3 Benefits Non Exercisers

The researchers saw improvements with the HMB/Vitamin D3 supplementation in the non exercise group. The exercisers did not show a statistically significant change.

The main finding of this study was that co-supplementation with calcium HMB and Vitamin D3 to healthy older adults improved the composite functional strength index and that this benefit was independent of a moderate resistance exercise program similar to that commonly practiced by older population on their own, the researchers concluded.

Vitamin D Role In Muscle Gain

The two most important functions of vitamin D in preserving health are frequently the immune system and bone metabolism. But theres more to consider when it comes to vitamin D.

Most people are unaware that adequate vitamin D levels are necessary to maintain peak athletic performance. Thats because it is essential for regulating the musculoskeletal system, the immunological system, the inflammatory response, protein synthesis, muscle function, cardiovascular function, and cell growth .

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Let Your Muscles Reach Their Full Potential

Its well known that myHMB can help build lean muscle mass, increase strength and improve muscle recovery. Recently, it has been shown that another nutrient, Vitamin D, is also essential for helping muscles to reach their full functional potential. When combined with HMB, Vitamin D optimizes the effectiveness of HMB.

This patented combination delivers two powerful muscle health ingredients clinically proven to each provide benefits to muscle health. But when put together, they create a powerful and synergistic effect. Created specifically to help achieve optimal muscle health, it can help women and men, athletes, weekend warriors, and active aging adults stay healthier, longer. These benefits to all major muscle groups can even be achieved without increased physical activity according to recent research.

With myHMB + Vitamin D, people of all ages and activity levels can:

  • Improve muscle mass and muscle function
  • Improve muscle strength and mobility
  • Strengthen bones to withstand activity, exercise, or strength training

Effect Of Hmb And Vitamin D Supplementation On Osteosarcopenia In Older Persons

Klean Athlete
Research Opportunity
PhD students, Masters by Research
Department / Centre
Personal web page

Summary Unfortunately, advancing age may comprise musculoskeletal health, with osteoporosis and sarcopenia two chronic diseases, which together form a geriatric syndrome, coined osteosarcopenia. This syndrome predisposes an older person to increased risk of falls and fractures, compared to either disease alone, and induces alarming health care costs.

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May Help Reduce Muscle Breakdown

Research suggests HMB may help reduce muscle breakdown.

Test-tube studies suggest that HMB may help prevent muscle breakdown in various ways inside cells, such as by suppressing genes and enzymes that promote the breakdown of muscle proteins .

An analysis of 15 studies looked at the effects of taking HMB in 2,137 people. These participants had health conditions that promote muscle loss, such as cancer, HIV, kidney failure, and malnutrition .

The analysis found that taking 34 grams of HMB daily over a period of 7 days to 6 months was significantly more effective at preventing muscle loss than a placebo .

Similarly, other studies in older people have shown that taking HMB can help preserve muscle mass during periods of bed rest .

However, scientists need to do more research on HMB and its potential protective effects against muscle breakdown in a wider variety of participants, such as young people and healthy adults, before recommending it for this purpose.

What Is Vitamin D

Vitamin D is a fat-soluble vitamin that belongs to the same chemical family as vitamins D1, D2, and D3. Sunlight exposure causes your body to naturally produce vitamin D. To maintain optimal vitamin D levels in your blood, you can also get it from specific meals and supplements.

Vitamin D plays key critical roles in the body. Most importantly, controlling calcium and phosphorus absorption and promoting healthy immune system function .

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How Much Hmb Should I Take

HMB is considered generally safe, with a low risk for side effects when taken by most healthy adults. There is currently no standardized dosage, but most studies have used three grams of HMB daily as the recommended dose.

You should not take more than the amount recommended on the products label or defer from the directions provided by your doctor.

As with any new dietary supplement, its essential to speak with your medical provider before taking an HMB supplement, especially if your medical history includes a preexisting health condition or any current medications.

Bottomline: Hmb And Vitamin D

HMB Supplement Review

The body naturally produces HMB when the branched-chain amino acid leucine breaks down. According to some research, it could prevent muscle loss and promote workout responses. Additionally, it might promote muscular growth in older persons and untrained people.

Taking HMB along with Vitamin D may provide additional benefits due to the connection it brings to the body. Studies have shown that appropriate vitamin D levels may be crucial to getting the best HMB results. However, like every other supplement available in the market, it is important to discuss with your doctor whether mixing HMB and vitamin D may benefit your health needs, as the effect may differ based on your bodys response.

Disclaimer: This article is only a guide. It does not substitute the advice given by your healthcare professional. Before making any health-related decision, consult your healthcare professional.

Editorial References And Fact-Checking

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Hmb And Vitamin D: Should I Mix Them

HMB, also known as beta-hydroxy beta-methylbutyrate, is a well-known dietary supplement that has drawn a lot of interest from the health and fitness world due to its potential to promote exercise performance and muscle building. But what happens if you combine it with vitamin D, one of the most well-known vitamins available?

Read on to find out if you should mix HMB and Vitamin D in terms of their benefits for athletic performance.

What Is Hmb Supplement Used For

While not enough human trials have been carried out to assess the actual long-term effects of HMB, current research suggests that it has prospective benefits.

One study suggested a positive correlation between HMB and muscle growth, provided that individuals also performed resistance training . Another review involving 7 different studies suggested a muscle gain in individuals of approximately 0.78 pounds after using HMB for more than 2 months .

On the other hand, few major studies done on HMB showed no muscle growth due to HMB consumption. There were no changes in body composition parameters, and overall strength remained unaffected even after taking the HMB dosage for considerable days .

One study involving patients with certain conditions, like AIDS and cancer, showed that these affected individuals were able to retain muscle despite their health condition. This means that HMB has the potential to help individuals improve lean muscle mass.

The results from another study suggest that HMB may promote fat loss and enhance athletic abilities. Subjects that used the HMB supplement generated more power in high-intensity workouts.

Again, there is still insufficient data, but HMB has shown in several studies that it is able to improve the recovery process and effectively heal wounds. Its also been shown to reduce the expression of inflammatory markers such as TNF- and IL-8.

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What You Need To Know About Hmb

Where performance supplements are concerned, HMB isnt one that often comes to the forefrontbut it should. For anyone looking to enhance overall athleticism, HMB is gold.

Before we can get into the nitty-gritty of HMB, we first have to talk about something most fitness enthusiasts and athletes are familiar withleucine. Of the amino acids, leucine takes the cake for being the most anabolic.

Of the three branched-chain amino acids, leucine exhibits the highest oxidation rates, which is the primary reason why its so thoroughly investigated.

Studies show that consuming BCAAs with a minimum of 30-35% leucine before or during endurance exercise may help to reduce the net rate of protein degradation, improve mental and physical performance, and may exhibit glycogen sparing effect to prevent muscle glycogen degradation and depletion of muscle glycogen stores 1.

All of these equates to better muscle growth and preservation and drastically reduces the chance of muscle loss. So, theres no denying that leucine offers quite the list of benefits for athletes, but what does it have to do with HMB?

Its been suggested that the anti-catabolic effects of leucine may be attributed to a specific compound called beta-hydroxy-beta-methylbutyrate, more commonly known as HMB, that is a metabolic by-product of leucine breakdown.

High Impact Plant Protein

MegaZorb Mega Magnesium Muscle Plus

A unique blend of powerful plant proteins, HMB, vitamin D3, and digestive enzymes designed to nourish your muscles, support your strength, and support the preservation of lean muscle.

  • Vegan protein blend supports healthy muscle development*

  • HMB and vitamin D3 supports maintenance of lean muscle mass, even on rest days*

  • Prohydrolase promotes healthy nutrient absorption and smooth digestion*

  • Chlorella contains antioxidants to support whole-body wellness*

  • Chromium helps transport amino acids to your muscles where they can get to work*

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Benefits Of Hmb Supplements

Studies have shown that taking HMB may offer several benefits, especially concerning body composition and physical performance. In addition, taking HMB is said to help promote muscle growth and reduce muscle breakdown.

However, while current research points to many potential benefits, its important to note that additional research is needed to understand HMBs full impact.

Lets look at some of the benefits HMB supplements can bring to your fitness routine.

Best Value Hmb Supplement Bulk Supplements

Bulk Supplements offers 100g of HMB for $13.96, making each serving come out to less than $0.14 total. This HMB powder is free of added sugar and allergens, making it suitable for practically any customer.

Bulk Supplements sells the most affordable HMB supplement and on top of that also offers the most options for serving sizes, with quantities ranging from 3.52 oz to 11 lbs.


  • Powder form is easiest for splitting dosages


  • Doesnt come with a serving spoon

  • The powder may not have a pleasant taste

  • Some customers may prefer capsules

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May Aid Exercise Adaptations

Some research has indicated that HMB could improve adaptations to exercise. This refers to a longer-term change rather than an immediate one.

For example, a 12-week study in 16 elite rowers found that taking 3 grams of HMB daily significantly increased aerobic exercise capacity and peak anaerobic power, and helped reduce body fat, compared with a placebo .

Anaerobic power refers to the maximum power you can produce during high-intensity exercise.

Similarly, another 12-week study in 42 combat sports athletes found that taking 3 grams of HMB daily significantly increased both aerobic and anaerobic exercise capacity, compared with a placebo .

Other studies in athletes and healthy adults have shown that taking 3 grams of HMB daily has similar effects on aerobic and anaerobic capacity .

What Does Hmb Stand For

myHMB + Vitamin D3 | NIH Study

HMB, also known as Beta-hydroxy-beta-methylbutyrate, is produced naturally in the body due to an amino acid breakdown . Among various amino acids that perform different functions inside our body, leucine helps stimulate protein synthesis and inhibit protein breakdown, especially in muscles.

When our body breaks down this branched-chain amino acid, leucine, HMB is produced. However, only 5% of leucine is broken down to produce HMB , due to which supplements are often taken to avail its maximum benefits.

Disclaimer: The content on and the information included in this article is intended for entertainment and informational purposes only. It is not intended nor implied to be a substitute for professional medical advice. Prior to buying anything, check that it is compliant where you live with your current government laws. Your access is subject to our full Terms of Use.

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Can I Really Afford It

This might seem like an obvious question, but it’s one that many people don’t think to ask themselves when they want something badly enough. Before you go out and buy protein powder with hmb and vitamin d that’s way beyond your budget, make sure you can afford it. It’s easy to get carried away when looking at price tags after all, retailers are trying to sell their products as much as possible but if the item costs more than you’re willing to spend on it, then it probably isn’t worth buying in the first place.

So, first, you need to determine if you really have the money for the protein powder with hmb and vitamin d. Can you truly afford it? You need to ensure that the purchase isnt land you in debt. Additionally, you dont want the money you spend on this item to detract from something else you might want to buy or something that you truly do need.

Vitamin D For Athletic Performance

On the other end of the spectrum, we have one of the most popularbut also the most deficientnutritional supplements around, vitamin D. Of the many roles vitamin D plays in maintaining health, its role in bone metabolism and immune function often top the charts. But where vitamin D is concerned, theres more.

Most people arent aware that sufficient vitamin D levels are actually needed to maintain optimal athletic performance. Thats because it plays critical roles in immune function and the inflammatory response, protein synthesis, muscle function, cardiovascular function, cell growth, and musculoskeletal regulation 7.

Studies consistently show links between low vitamin D status and poor athletic outcomes, but boosting levels through supplementation can improve muscle strength, reduce rates of injury, and better sports performance.


Vitamin D exerts its actions through two pathways: endocrine and autocrine functions 6, 7.

The endocrine mechanism is responsible for what we typically know vitamin D forbone metabolism via calcium regulation. Vitamin D promotes calcium uptake from the gut and enhances osteoclastic activity, thereby supporting bone growth, bone mineral density, and bone remodeling.

When vitamin D concentrations fall below the normal threshold, parathyroid hormone increases bone resorption to meet the bodys demand for calcium.

  • Signaling processes
  • Immune function and inflammatory response

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Questions To Ask Yourself Before You Buy Protein Powder With Hmb And Vitamin D

So often, we buy something, sure that we need it, only to find that its not really something we use again or truly need. Before you buy protein powder with hmb and vitamin d, its a good idea to ascertain that you actually need it and that it fits in with your long-term financial priorities.

Before you buy something that you need, take a step back and determine whether you really should buy that item.

Here are questions to ask yourself answer honestly:

  • Can I really afford it?
  • What will I do with it?
  • How often will I use it?
  • Do I really even want it?
  • Is this a need or a want?
  • Can I borrow it?

Here are the answers you need to make the best purchase:

What Will I Do With It

HMB 4500

This is one of the important questions that should be asked before you buy protein powder with hmb and vitamin d. If you don’t know what you’ll use it for, don’t buy it. Take some time to research the product before buying anything.

Many people out there have no idea what they want but still buy things because they feel like they have to have it. It’s not a good idea to do this when shopping for something that costs a lot of money.

If you can’t answer this question, chances are good that you don’t need protein powder with hmb and vitamin d at all. You should always consider what purpose a particular item will serve before buying it and ensure that it serves that purpose well enough for your needs.

For example, if you want to cook dinner at home more often and want to buy an electric pressure cooker to make things easier on yourself, but your kitchen only has one electrical outlet, and it’s used by your mixer or food processor, then maybe an electric pressure cooker isn’t really necessary.

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Study: Hmb Plus D3 Improves Muscle Function In Older Adults

The combination of HMB and Vitamin D3 has the potential to enhance muscle strength and physical functionality in older adults, even without exercise, according to research published in The Journals of Gerontology. The year-long randomized, double-blind, placebo-controlled study indicates was supported by a grant from the National Institutes of Health .

A press release from TSI USA, LLC, which produces and markets the branded ingredient myHMB, discussed the science, explaining that HMB stimulates protein synthesis and reduces muscle breakdown, while higher vitamin D3 levels are associated with greater strength and superior muscle function, especially in older adults. With this study, we now understand HMB and vitamin D3 can have a synergistic effect in older adults, superior to what either can do individually, said lead researcher John Rathmacher, Ph.D., in the release. Dr. Rathmacher serves as Director of Clinical Research and Laboratory Services at Metabolic Technologies, LLC, the company that discovered HMB and is now owned by TSI.

In the study, 117 healthy adults ages 60 and older were assigned to take HMB + Vitamin D3 or a placebo. Half of the subjects in each group participated in a mild resistance training program consisting of 60-minute supervised progressive resistance training sessions, three days a week the other half did not exercise. Physical function, muscle strength, and body composition were measured at three-month intervals.


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