Top Best Answers To The Question What Is A Toxic Level Of Vitamin D For Dogs
Vitamin D Toxicity in Dogs.
Vitamin D is an essential nutrient that helps dogs regulate the balance and retention of calcium and phosphorus.
However, extremely high levels of vitamin D can cause serious health problems.
Causes of Vitamin D Poisoning in Dogs It can take as little as a dose of 0.1 mg/kg to cause vitamin D poisoning. That’s about 0.45 mg per 10 pounds of body weight. The fatal dose is around 2 mg/kg, which equals about 9 mg in a 10-pound dog.
Symptoms of Vitamin D toxicosis can be seen with doses as low as 0.1mg/kg, and a lethal dose in a mature dog can be as low as 2mg/kg .
Those who are looking for an answer to the question «What is a toxic level of vitamin d for dogs?» often ask the followingquestions:
Vitamin D And Your Dog
We humans are lucky we can get our vitamin D3 not just from diet, but from exposure to the sun.
But dogs and cats are different. They only get insignificant amounts from the sun and must get nearly all of their vitamin D from their diet.
There are two types of vitamin D: vitamin D2 and vitamin D3 .
When vitamin D3 is eaten by your dog, it needs to be converted into a usable form .
Vitamin D3 is first absorbed through the intestines, then converted in the liver to 25-hydroxyvitamin D . The active form of vitamin D that the body uses is 1,25-dihydroxyvitamin D, also called calcitriol.
*table source: vdilab.com/page.php
Vitamin D is mainly responsible for the absorption of calcium and phosphorus in the body. This affects a large range of functions in the body.
Vitamin D toxicity is the result of too much vitamin D in the diet. Over the years, many commercial pet foods have added too much vitamin D to their foods and its caused illness and even death in the animals eating it.
If theres too much vitamin D in the diet, then life-threatening levels of calcium and phosphorus can occur. This result is hardening or calcification of body tissues. This often occurs in the kidneys gastrointestinal tract, the heart and its arteries. Kidney failure can occur within days if vitamin D levels are high enough.
Heres a list of research showing some of the diseases that are associated with low serum levels of vitamin D: vdilab.com/pdf/40_VitD%20-%20body%20of%20evidencev7.pdf
What Nuts Are Toxic To Dogs
Nuts that are okay for dogs to eat include peanuts, almonds and cashews.
As with any new foods, caution should be exercised: according to the ASPCA, the high fat content in nuts can cause vomiting and diarrhea in dogs.
Dog owners should not feed their pups macadamia nuts or black walnuts, as both can cause problems.
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Do Our Dogs Need To Be Outdoors More Often
What we can learn from the biology is that if you have a healthy dog with no signs of vitamin D or calcium deficiency, having less sun will not impact their vitamin D production to a great degree. It is very unlikely a dog with a normal diet would become vitamin D deficient due to a lack of sunlight. Sunlight, of course, has a number of other health benefits, so being outside frequently is highly recommended. Be wary that the same UV light that helps create a lot of vitamin D in humans, and a tiny amount in dogs, can be dangerous. UV light damages dog skin in the same way as it does human skin. Particularly lighter skin and skin with less hair. Dogs can be sunburnt and long-term UV light exposure can increase the risk of skin cancers. These can be prevented in the same way we protect our skin. Reducing long-term sunlight exposure, staying out of direct sunlight, and using suntan lotion on pink or white skin .
How To Shop For Quality Dog Food
This recall can lead many of us to wonder what foods are safe for our pets. Proper nutrition keeps your pet energized day-to-day, and can even help prevent diet-associated diseases as well as aid in the management of other diseases. However, often times the best thing a pet food has going for it is an attractive label. Also, we as consumers can fall into the trap of thinking that because something costs more it must also have higher quality ingredients or more nutritional value.
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What Care Is Required After Treatment
Unfortunately, the effects of vitamin D poisoning can last many weeks to months. Blood work to monitor calcium, phosphorous, and kidney function are typically recommended following discharge from the hospital. If elevations in calcium, phosphorous, or kidney values occur, monitoring may need to be continued for many weeks. Some dogs may require further hospitalized care since calcium levels may increase again following initial treatment. Kidney damage may occur in dogs that develop high calcium levels. They may require long-term management for kidney failure including blood work monitoring, fluid therapy, anti-nausea medications, medications to control blood pressure and antacids.
Pet Poison Helpline, an animal poison control center based out of Minneapolis, MN is available 24/7 for pet owners and veterinary professionals that require assistance treating a potentially poisoned pet. The staff provides treatment advice for poisoning cases of all species, including dogs, cats, birds, small mammals, large animals and exotic species. As the most cost-effective option for animal poison control care, Pet Poison Helplines fee of $65 per incident includes follow-up consultations for the duration of the poison case. Pet Poison Helpline is available in North America by calling 800-213-6680. Additional information can be found online at www.petpoisonhelpline.com
What Fruits Are Toxic To Dogs
In the same way that chocolate is toxic to cats and dogs, some fruits and vegetables are too.
Onions, garlic, wild mushrooms, avocado, and rhubarb are all poisonous to pets, and corn is also a common allergen.
You should also avoid feeding grapes and raisins to your pet, as they can cause kidney damage.
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Treatment Of Acute Vdt
Any one of vitamin D’s three forms may lead to VDT. Toxicity from vitamin D2 or D3 is harder to manage than toxicity due to vitamin D’s metabolites . That is partly due to the long half-life in the body because of vitamin D’s high lipid solubility in the liver, muscles, and fat tissues and the corresponding large storage capacity .
Thus, hypercalcemia due to a vitamin D overdose theoretically can last up to 18 months after the administration of vitamin D is discontinued. That is because of the slow release of the stored vitamin D from fat deposits. However, the half-lives of 25D and 1,252D in the body are much shorter, at 15 days and 15 h, respectively. Therefore, an overdose of 25D may persist for weeks, whereas that related to 1,252D lasts only a few days .
Treatment of VDT consists of first- and the second-line treatment strategies . First-line treatment includes the following:
Second-line treatments of VDT include the following:
Recovery Of Vitamin D Poisoning In Dogs
The prognosis for vitamin D poisoning depends upon if and when treatment is sought however, if treatment occurs early, the prognosis is very good. Your day may require prolonged hospitalization and monitoring. Even after your dog is released to outpatient care, you may have to return to your veterinarian regularly in order to monitor progress. Your pet needs to be monitored for potential organ calcification, caused by the buildup of calcium in body tissues, which hardens and can disrupt bodily functions.
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Vitamin D Poisoning Average Cost
From 31 quotes ranging from $500 – $7,500
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Diagnosis Of Vitamin D Poisoning In Dogs
As the symptoms of vitamin D poisoning overlap with many other conditions, it is important to disclose details about your dogs diet, any supplements you have been adding, and if your dog may have been able to access rodenticides or another source of vitamin D recently. Being able to determine that vitamin D poisoning is causing your dogs symptoms will aid in a swift recovery.
The veterinarian will conduct a complete physical examination, and conduct a complete blood count, which checks for abnormalities in red and white blood cell count. Additionally, a blood biochemistry profile will measure levels of calcium and phosphorous, elevated levels of which indicate vitamin D poisoning. The biochemistry profile may also show lower than normal levels of potassium and an accumulation of nitrogenous waste products, as well as low levels of albumin and high levels of certain liver enzymes. A urinalysis will be conducted to measure levels of proteins and glucose, which, if elevated, will help confirm the diagnosis. In some cases, an echocardiogram will measure your dogs heartbeat, as some dogs suffering from vitamin D poisoning have slowed heartbeats.
Getting Into Vitamin D Supplements
Some dogs like to get into anything and everything they can find. When a dog finds Vitamin D supplements, they are usually human supplements that the owner accidentally left within reach. If your dog gets into your medications and eats your Vitamin D supplements, he can easily get enough to cause toxicosis.
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Some Dog Food Has Toxic Levels Of Vitamin D Fda Warns
Several popular brands of dog food have up to 70 times the safe levels of vitamin D and could kill dogs who eat them, the Food and Drug Administration warned Monday.
The makers of at least 11 different labels or brands of dog food are recalling their products and people need to check before feeding any dry food to their dogs, the FDA said.
Testing found that samples of the dog food contained excessive, potentially toxic amounts of vitamin D. Vitamin D is an essential nutrient for dogs, but very high amounts can cause serious health problems like kidney failure or death, the FDA said.
Excess vitamin D in the diet can cause vomiting, loss of appetite, increased thirst, increased urination, excessive drooling and weight loss. Vitamin D at toxic levels can cause kidney failure and death. Pet owners whose dogs have been eating the recalled brands and are showing these symptoms should contact their veterinarians.
Cases Of Salmon Dog Food Recalled Due To Elevated Levels Of Vitamin D
On October 11, 2021, Tuffys Pet Foods issued a voluntary recall of roughly 1,600 cases of Nutri Source Pure Vita Salmon Entree Dog Food in a Tetrapak carton due to elevated levels of Vitamin D.
The FDA warns that dogs of all sizes consuming very high levels of Vitamin D could have adverse reactions.
The recall was initiated following a notification from the product manufacturer for the potential of elevated levels of Vitamin D. The issue has been identified and corrective actions are in process to prevent it from happening again. The pet food company reassured consumers that no other Pure Vita products were impacted and said they issued the recall out of an abundance of caution.
No illnesses have been reported but consumers are urged to stop feeding the product listed below.
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Treatment Of Vitamin D Poisoning In Dogs
If your dog has recently ingested the substance at the time you seek treatment, the veterinarian will induce vomiting and administer a drug that binds to the vitamin D in order to prevent further absorption. However, if the substance has already been fully metabolized, the first goal of treatment will be to stabilize your dog if necessary, as in the case of a dog suffering seizures. Your dog will be placed on an IV in order to stay hydrated and balance electrolyte levels. Hydration helps to encourage the excretion of excess calcium through urine.
The veterinarian will monitor calcium and phosphorus levels frequently until they have stabilized enough to take your dog off of the IV. After this, the veterinarian will likely want to monitor your dogs levels daily for several days to avoid renal failure. In some cases, aluminum hydroxide, or other phosphate binders will be given to lower the phosphate levels.
Other treatments include the administration of anti-seizure medication, antibiotics in the case of secondary bacterial infections that may occur as a result of vitamin D poisoning, and/or blood transfusion in the case of severe anemia.
What Do Pet Owners Need To Do
If your pet is having symptoms of vitamin D toxicity, contact a veterinarian immediately. Provide a full diet history to your veterinarian. You may find it helpful to take a picture of the pet food label, including the lot number.
Donât feed the recalled products to your pets or any other animal. Contact the company listed on the package for further instructions or throw the products away in a way that children, pets and wildlife cannot access them.
You can report suspected illness to the FDA electronically through the Safety Reporting Portal or by calling your stateâs FDA Consumer Complaint Coordinators. Itâs most helpful if you can work with your veterinarian to submit your petâs medical records as part of your report. For an explanation of the information and level of detail that would be helpful to include in a complaint to the FDA, please see How to Report a Pet Food Complaint.
The Process Of Acute Vdt
VDT resulting from excessive use of vitamin D is characterized by hypercalciuria, hypercalcemia, elevated 25D > 150 ng/ml , and usually normal or slightly increased 1,252D concentration.
Ten years ago, Jones suggested three major hypotheses about the mechanism of VDT. All three involve increased concentrations of a vitamin D metabolite reaching the vitamin D receptor in the nucleus of target cells and causing exaggerated gene expression. The three hypotheses to explain VDT are as follows:
Toxicity is mediated by increased serum concentrations of the active hormonal form, 1,252D, which lead to its increased intracellular concentration. That hypothesis is not strongly supported. Only one study, Selby et al. reported elevated 1,252D concentration values at VDT. Many other studies revealed that 1,252D concentrations were normal or only slightly elevated.
1,252D has a low affinity for vitamin D binding protein and a high affinity for VDRs, making it an important ligand with access to the transcriptional signal transduction machinery. In hypervitaminosis D, the concentrations of various vitamin D metabolites, especially 25D, are markedly increased, saturating the binding capacity of VDBP and in turn enabling other vitamin D metabolites to enter the cell nucleus. Among the various vitamin D metabolites, 25D in higher concentrations has the strongest affinity for VDRs, so that particular metabolite at its high serum concentrations stimulates transcription by itself .
The Link To Cancer And Disease
Now, in my six years of university, I learned a lot about looking for something called Cause And Effect when I examine research.
The key part of cause and effect is proving the effects seen in the experiment happened after the cause.
Cause and effect is one of the most commonly misunderstood concepts in science and is often misused by lawyers, the media, politicians and even scientists themselves, in an attempt to add legitimacy to research
In the case of the above study, the researchers would have to show that low 25VitD actually caused cancer.
But this isnt the case
theres merely an association.
The above study means we only know more dogs with cancer have lower 25-VitD than dogs without. It doesnt tell us that low levels of 25VitD can cause an increased risk of cancer.
In fact, it could mean that cancer reduces the dogs ability to make 25-VitD from dietary vitamin D.
Heres a study that might actually show this
In 2004, researchers measured 25VitD in dogs with lymphoma , hyperparathyroidism and kidney failure. What they found was the dogs with these diseases had lower levels of 25VitD than the healthy control dogs.
Now heres the important part
As the diagram at the start of the article shows, 25VitD is just a precursor to the usable, active form of vitamin D, called 1,25-dihydroxycholecalciferol.
Scientists cant measure this important form of vitamin D they can only measure its precursor 25VitD.
Why is it important to know this?
How Much Vitamin D Is Too Much
Since relatively little is known about how vitamin D toxicity works, it is hard to define an exact threshold for safe or toxic vitamin D intake .
According to the Institute of Medicine, 4000 IU is the safe upper level of daily vitamin D intake. However, doses up to 10,000 IU have not been shown to cause toxicity in healthy individuals (
Hypercalcemia caused by regularly taking high amounts of vitamin D supplements may take a few months to resolve. This is because vitamin D accumulates in body fat, and is released into the blood slowly .
Treating vitamin D intoxication includes avoiding sun exposure and eliminating all dietary and supplemental vitamin D.
Your doctor may also correct your calcium levels with increased salt and fluids, often by an intravenous saline.
The main consequence of vitamin D toxicity is hypercalcemia, with symptoms including nausea, vomiting, weakness and kidney failure. Treatment involves limiting all vitamin D intake and sun exposure.
Symptoms Of Vitamin A Toxicity
Vitamin A toxicity can occur when a dog ingests too much vitamin A. Sometimes this occurs accidentally, as when a puppy consumes a bottle of vitamin A supplements, but in other cases, it occurs inadvertently when an owner gives a dog too much vitamin A. These cases include overuse of fish liver oil supplements or overfeeding of liver.
Symptoms of canine vitamin A toxicity include:
- appetite loss