Hydroxyvitamin D Level Test
25 hydroxyvitamin d monitoring is useful in people who are at risk of suffering from vitamin D deficiency. 25 hydroxyvitamin d test is also useful if you are already found to have vitamin D deficiency.
- People who are less exposed to sun rays.
- Patients who have undergone gastric bypass surgery.
- People who are overweight.
- Elderly individuals.
- People having intestinal problems who cannot absorb this fat soluble vitamin such as irritable bowel syndrome or Chrons disease etc.
How Is The 25
Your doctor will tell you not to eat anything for four to eight hours before the test.
The 25-hydroxy vitamin D test requires a common blood test. Your healthcare provider will draw blood from a vein in your arm using a needle. A quick finger prick will more than likely provide enough for a blood sample in children and infants.
Results will depend on your age, sex, and the testing methods used. Results can also slightly vary from lab to lab.
According to the , levels of vitamin D are measured by the 25-hydroxy level in nanomoles/liter or nanograms/milliliter . The results can indicate the following:
- deficiency: less than 30 nmol/L
- potential deficiency: between 30 nmol/L and 50 nmol/L
- normal levels: between 50 nmol/L and 125 nmol/L
- high levels: higher than 125 nmol/L
If your vitamin D levels are low and youre having symptoms of bone pain, a doctor may recommend a special scan to check bone density. Doctors use this painless scan to evaluate a persons bone health.
Low blood levels of 25-hydroxy vitamin D usually mean one of the following:
- you arent eating a balanced, complete diet
- your intestines arent absorbing the vitamin properly
- youre not spending enough time outside to absorb adequate vitamin D levels through sun exposure
Some evidence links vitamin D deficiency to a higher risk of certain cancers, immune diseases, and cardiovascular disease.
High levels are rarely due to consuming too much of the vitamin through foods or sun exposure.
- excessive bleeding
Data Source And Subjects
The third National Health and Nutrition Examination Survey was conducted between 1988 and 1994 to study the health and nutritional status of a nationally representative sample of the noninstitutionalized US population. The survey oversampled older persons, non-Hispanic black persons, and Mexican Americans.
Interviews were conducted at respondents’ homes. Standardized clinical examinations, including blood sampling and functional measurements , in respondents aged 60 y were conducted in mobile examination centers and at the homes of participants . Of 8375 respondents in that age group, 6866 consented to an interview and 5740 were examined in the mobile examination centers. Physical performance tests were performed in 5403 subjects . For this analysis, the final sample consisted of 4100 subjects aged 60 y for whom there were complete data on the timed 8-foot walk test, the repeated timed sit-to-stand test, and serum 25D concentration. Of these 4100 subjects, 49% were female, 58% were non-Hispanic white, 19% were non-Hispanic black, and 20% were Mexican American. The study protocol for this analysis was approved by the Human Research Committee of the Brigham and Women’s Hospital in Boston .
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Vitamin D 25 Hydroxy Low Symptoms
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41.6% of adults in the USA dont get sufficient vitamin D, and other people with darkish pores and skin have extra prone to be poor. Fatigue, bone ache, muscle weak spot, despair, hair loss are simply a number of the circumstances linked to a vitamin D deficiency.
What Causes Vitamin D Deficiency
In general, the two main causes of vitamin D deficiency are:
- Not getting enough vitamin D in your diet and/or through sunlight.
- Your body isnt properly absorbing or using vitamin D.
There are several specific causes of vitamin D deficiency, including:
- Certain medical conditions.
- Weight loss-surgeries.
- Certain medications.
Several different biological and environmental factors can also put you at a greater risk of developing vitamin D deficiency, such as older age and the amount of melanin in your skin.
Medical conditions that can cause vitamin D deficiency
Medical conditions that can cause vitamin D deficiency include:
- Cystic fibrosis, Crohn’s diseaseand celiac disease: These conditions can prevent your intestines from adequately absorbing enough vitamin D through supplements, especially if the condition is untreated.
- Obesity: A body mass index greater than 30 is associated with lower vitamin D levels. Fat cells keep vitamin D isolated so that its not released. Obesity often requires taking larger doses of vitamin D supplements to reach and maintain normal levels.
- Kidney disease and liver disease: These conditions reduce the amount of certain enzymes your body needs to change vitamin D to a form it can use. A lack of either of these enzymes leads to an inadequate level of active vitamin D in your body.
Weight-loss surgeries and vitamin D deficiency
Medications that can cause vitamin D deficiency
Certain medications can lower vitamin D levels, including:
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Usual Gait Speed And Handgrip Strength Measurement
Usual gait speed and handgrip strength were measured prior to a midweek dialysis session. Participants usual gait speed was assessed using 6-m walking tests . Each participant was asked to complete two trials with a standing start. Participants were instructed to walk at their usual pace until they reach the finish line. One trained interviewer walking alongside the participants recorded the time from the start line to the stop line using a hand-held stopwatch following standardized procedures. Total course time was converted to meters/second . Participants could use walking aids if necessary but not the assistance of another person .
Handgrip strengths, in kilogram-force, were measured using a Jamar dynamometer in the dominant hand or the non-fistula hand if implanted before a dialysis session according to previous studies . The dynamometer was calibrated before each measurement day. The standard positionings recommended are sitting with 90 degrees of elbow flexion . In order to achieve the best performance, patients were instructed to adjust the dynamometer so it fits comfortably to their hand size by an experienced research staff blinded to all clinical and biochemical data of the patients. The arm should be extended sideways from the body, with the dynamometer facing away. Encouragement was given while doing so. Each trial was repeated three times with intervals of 60 s and the maximum value was used .
How Is Vitamin D Deficiency Diagnosed
Healthcare providers dont usually order routine checks of vitamin D levels, but they might need to check your levels if you have certain medical conditions or risk factors for vitamin D deficiency and/or have symptoms of it.
Your provider can order a blood test to measure your levels of vitamin D. There are two types of tests that they might order, but the most common is the 25-hydroxyvitamin D, known as 25D for short.
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Why Is A 25
Your doctor may request a 25-hydroxy vitamin D test for several different reasons. It can help them figure out whether too much or too little vitamin D is causing bone weakness or other abnormalities. It can also monitor people who are at risk for having a vitamin D deficiency.
Those who are at high risk of having low levels of vitamin D include:
- people who dont get much exposure to the sun
- babies who are breastfed only
- people who have had gastric bypass surgery
- people who have a disease that affects the intestines and makes it difficult for the body to absorb nutrients, such as Crohns disease
Your doctor may also want you to do a 25-hydroxy vitamin D test if theyve already diagnosed you with a vitamin D deficiency and want to see if treatment is working.
The Best Way To Forestall A Vitamin D Deficiency Vitamin D 25 Hydroxy Low Symptoms
Though were spending extra time indoors away from the daylight, which decreases our skill to supply vitamin D, it additionally lowers one danger issue for pores and skin most cancers. Thats vital, particularly for teams of individuals with darker pores and skin who would want longer publicity to supply the identical quantity. And with different methods of getting vitamin D, probably harmful time in direct daylight with out sunscreen isnt obligatory. The most secure and easiest way of prevention could also be within the kitchen.Inventory your kitchen with good meals sources of vitamin D equivalent to fatty fish , egg yolks, beef liver, dairy merchandise, and fortified meals equivalent to orange juice and sure breakfast cereals. Simply dont go too loopy, or add a complement to your routine, until youve had your vitamin D standing checked. Your vitamin D consumption could also be ample in case youre consuming a number of of those meals, because the really helpful dietary allowance for adults may be hit by from meals sources alone.
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How Prevalent Is Vitamin D Deficiency And Who Is At Risk
Worldwide, naturally occurring dietary sources of vitamin D are limited, and food fortification is optional, inconsistent, inadequate, or nonexistent. Therefore, for most people, vitamin D is primarily obtained by cutaneous production from sun exposure. However, many variables influence the amount of UVB from sunlight that reaches the skin and its effectiveness. These include time of day, season, latitude, altitude, clothing, sunscreen use, pigmentation, and age. In Minnesota in 2008, less than half of days provided enough solar UVB radiation at noon to effect cutaneous vitamin D production.2 Even those who normally reside in sunny climates are commonly found to be deficient in vitamin D, probably due to cultural habits and/or dress.3 Even if regularly exposed to sunlight, elderly people produce 75% less cutaneous D3 than young adults.4 Further barriers to cutaneous vitamin D production are ongoing public health campaigns promoting sunscreen use, as advocated by the American Academy of Dermatology . Unfortunately, commonly recommended daily intakes of vitamin D are known to be insufficient if sunlight exposure is limited.5
Frequent Illness Or Infections
One of the most important roles of vitamin D is supporting immune health, which helps you ward off viruses and bacteria that cause illness.
Vitamin D directly interacts with the cells that are responsible for addressing infections .
If you often become sick, especially with colds or the flu, low vitamin D levels may be a contributing factor. Several large observational studies have shown a link between a deficiency and respiratory tract infections such as colds, bronchitis, and pneumonia (
Recently, vitamin D deficiency has been linked to an increased risk of COVID-19, as well as an increased risk of experiencing severe effects from the condition. However, it is important to note that taking vitamin D supplements at any dosage will not prevent COVID-19 .
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Causes Of Vitamin D Deficiency
Vitamin D deficiency can occur for a number of reasons:
You don’t consume the recommended levels of the vitamin over time. This is likely if you follow a strict vegan diet, because most of the natural sources are animal-based, including fish and fish oils, egg yolks, fortified milk, and beef liver. Here are the best vitamin d foods for vegetarians.
Your exposure to sunlight is limited. Because the body makes vitamin D when your skin is exposed to sunlight, you may be at risk of deficiency if you are homebound, live in northern latitudes, wear long robes or head coverings for religious reasons, or have an occupation that prevents sun exposure. Duirng the winter, vitamin D deficiency can be more prevalent because there is less sunlight available.
You have dark skin. The pigment melanin reduces the skin’s ability to make vitamin D in response to sunlight exposure. Some studies show that older adults with darker skin are at high risk of vitamin D deficiency.
Your kidneys cannot convert vitamin D to its active form. As people age, their kidneys are less able to convert vitamin D to its active form, thus increasing their risk of vitamin D deficiency.
Your digestive tract cannot adequately absorb vitamin D. Certain medical problems, including Crohn’s disease, cystic fibrosis, and celiac disease, can affect your intestine’s ability to absorb vitamin D from the food you eat.
Serum Concentration Of 25d
Venous blood samples were taken in a standardized fashion in the mobile examination centers. Serum 25D concentrations were assayed with radioimmunoassay kits . The reference range for the assay is 22.594 nmol/L .
NHANES III contains an inherent season and latitude structure to the extent that data were collected in the northern latitudes during the summer and in the southern latitudes during the winter. This structure was taken into consideration in analysis of 25D concentrations because they have been shown to be affected by seasonality and latitude .
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Pinpointing A Healthy Vitamin D Level Is Tricky
So, what is the current cutoff value at which people are considered “low,” and thus at risk for developing bone thinning and having fractures? Ah. This is where there is a lot of argument.
In 2010, the venerable Institute of Medicine issued a report based on lengthy examination of data by a group of experts. To sum up, they estimated that a vitamin D level of 20 ng/mL or higher was adequate for good bone health, and subsequently a level below 20 was considered a vitamin D deficiency.
In my practice, and in most, it is not uncommon to see a vitamin D level less than 20. When that happens, we tell the patient that they are deficient and recommend fairly aggressive replenishment, as well as ongoing supplementation. The majority of folks have a level between 20 and 40, in my experience, and this is corroborated by the IOMs findings in that 2010 report.
But in 2011, the respected Endocrine Society issued a report urging a much, much higher minimum blood level of vitamin D. At that time, their experts concluded: “Based on all the evidence, at a minimum, we recommend vitamin D levels of 30 ng/mL, and because of the vagaries of some of the assays, to guarantee sufficiency, we recommend between 40 and 60 ng/mL for both children and adults.”
What Do The Results Of This Lab Test Mean
The results of 25 hydroxy vitamin D test will usually include the following details:
- Value of 25 hydroxy vitamin D3: The amount of vitamin D your body made on its own, absorbed through an animal source or from a cholecalciferol supplement
- Value of 25 hydroxy vitamin D2: The amount of vitamin D absorbed from fortified foods or from an ergocalciferol supplement
Apart from these values, the total amount of this test is also an important part of the test result. The test result is measured in the unit of nanograms per milliliter and can vary among labs. Note that the normal level of vitamin D is recommended between 20-40 ng/mL or 30-50 ng/mL . Apart from normal, the following can be the categorization of the results of the test for vitamin D 25 hydroxy low and high.
If your vitamin D level is higher than the recommend range, it may be because of hypervitaminosis D, a condition where a high amount of vitamin D accumulates in your body. This can result from your body having too much calcium, also known as hypercalcemia.
Vitamin D 25 hydroxy low levels are usually caused by the following factors:
- Liver or kidney disease
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How Long Can You Take 50 000 Iu Of Vitamin D
50,000 IU capsules are available by prescription only. If your blood levels are exceptionally low, you may need higher doses that should be used under the direction of a healthcare provider. In patients with vitamin D levels less than 20 ng/mL, start with 50,000 IUs of vitamin D3 once a week for 6 to 8 weeks.
What Can I Expect If I Have Hyperparathyroidism
Surgery will cure nearly all cases of hyperparathyroidism. If you have surgery, your provider may want to check your calcium and PTH levels six weeks after surgery, and then on a yearly basis. You may also have a bone density test every year as well.
If you have mild symptoms and do not need surgery right now, your provider will carefully monitor your health and order blood tests to check your calcium and PTH levels. He or she will also order tests to watch for bone loss and other tests as needed.
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Vitamin D 25 Hydroxy Blood Test Results Explained
The Vitamin D 25-hydroxy blood test is considered to be the most accurate method of determining how much of this vitamin is within the body. When it is in the kidneys, it is converted into an active vitamin that helps to control calcium and phosphate levels. It is only ordered when there is a suspicion that there is a vitamin deficiency or normal values must be verified before beginning a drug treatment.
This blood test can also be used to verify the health of individuals who struggle with fat absorption. This includes Crohns disease and Cystic Fibrosis as the vitamin is normally absorbed through the intestines because it is fat soluable. Once a deficiency has been identified, the Vitamin D 25-hydroxy blood test is also used on a continual basis to monitor treatment results.
A medical provider will order this blood test if there is the suspicion of an electrolyte imbalance or there is physical evidence of bone weakness or disease. Individuals who have had gastric bypass surgery to encourage weight loss may also have this test frequently ordered to monitor their health.