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Low Vitamin D And High Cholesterol

Sunshine Or Supplements Cholesterol Concerns Must Be Considered With Vitamin D Says Expert

Muscle Aches, Low Cholesterol & Vitamin D Deficiency Dr.Berg

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Speaking to NutraIngredients-Asia, Dr. Anuradha Khadilkar, deputy director of the Hirabai Cowasji Jehangir Medical Research Institute in Pune, India, said high doses of vitamin D supplementation could, in some cases, raise the overall lipid profile of an individual.

This, he said, should be considered by clinicians recommending high doses for deficiencies as well as the nutrition industry making vitamin D supplements and fortified foods.

Increases in cholesterol due to vitamin D supplements may be a health concern, he said.

Measuring cholesterol

Discussing his recently published research in the Indian Journal of Endocrinology and Metabolism, Khadilkar said a randomized control trial among middle-aged, vitamin D-deficient Indian men showed the negative side of supplementation.

A total of 203 men, aged 40-60, participated in the study and were split into three groups control, increased sunlight exposure and cholecalciferol supplementation.

The study ran for six months with daily interventions and an overall compliance of 95% and measured 25-Hydroxy vitamin D levels – the major circulating form of vitamin D and the precursor of the active form as well as total cholesterol , low-density lipoprotein cholesterol and high-density lipoprotein cholesterol levels.

Among the sunlight exposure group there was a significant decrease in TC of 9.4% and LDL-C also dropped 7.2%. A small decrease of 3.3% was also noted in the HDL-C levels for this group.

Vitamin D Improves Cholesterol Levels

Previous studies have linked vitamin?D deficiency to heart attacks, congestive heart failure, peripheral arterial disease, stroke and other conditions associated with cardiovascular disease, such as diabetes and high blood pressure. Other studies have also suggested that vitamin?D may have a beneficial effect on ones cholesterol profile and cardiovascular health.

To evaluate these findings, Dibaba analyzed 41 randomized controlled trials that examined the effect of vitamin?D supplementation on cholesterol levels. The studies involved more than 3,400 participants, half of whom took vitamin D supplements while the remaining half took a placebo. A quarter of the trials had follow-up periods of over six months.

Dibaba found that the volunteers who took vitamin D supplements significantly reduced their total cholesterol, LDL cholesterol and triglyceride levels, and maintained healthy HDL cholesterol levels. These improvements, according to the Dibaba, were more pronounced in the participants with vitamin D deficiency.

Effect Of Vitamin B12 Restriction On Plasma Vitamin B12 And Homocysteine Levels After 12 Weeks Of Feeding

After 12 weeks of feeding different experimental diets, we observed significantly decreased levels of vitamin B12 in both B12R+ and B12Râ mice as compared to control mice . The plasma homocysteine was also significantly high in both B12R+ and B12Râ as compared to the control mice. However, there were no changes in the plasma folate levels between the groups.

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How Is High Cholesterol Diagnosed

There are usually no signs or symptoms that you have high cholesterol. There is a blood test to measure your cholesterol level. When and how often you should get this test depends on your age, risk factors, and family history. The general recommendations are:

For people who are age 19 or younger:

  • The first test should be between ages 9 to 11
  • Children should have the test again every 5 years
  • Some children may have this test starting at age 2 if there is a family history of high blood cholesterol, heart attack, or stroke

For people who are age 20 or older:

  • Younger adults should have the test every 5 years
  • Men ages 45 to 65 and women ages 55 to 65 should have it every 1 to 2 years

Dna Methylation And Regulation Of Lipid Metabolism Through Low B12

Low Cholesterol And Vitamin D Deficiency

Methylation generally involves the process of transferring a methyl group to substrates such as enzymes, proteins, amino acids and DNA in diverse cells and tissues . In the process, guanine is normally bound with 5-methylcytosine following its development from cytosine . Usually, hypermethylation of global DNA and 5â²-cytosine-phosphate-guanineâ3â² islands located within the promoters of genes involved in lipid synthesis, accounts for the stability of the genome and silencing of the lipogenic genes, respectively . This is greatly dependent on the availability and sufficiency of SAM synthesized with the aid of methyl donors such as B12 and folate . Low B12 independently impairs the MS action affecting SAM/SAH ratio which is a principal determinant of the methylation potential of cellular DNA, thereby inducing dysregulation of gene expressions . Demethylation associated with DNA of the genome, persists as one of the earliest evidences of epigenetic modifications triggered by diets deficient in methyl donors, contributing to hepatocarcinogenesis in animals .

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Measurement Of Cholesterol And Homocysteine

Total cholesterol was determined fluorimetrically in cell lysates using Amplex Red cholesterol assay kit according to manufacturers protocol . Reduced homocysteine was chromatographically separated using ion-paired reversed-phase HPLC with oxidative mode electrochemical detection . Conditioned media or serum was reduced with 50 mM DTT at 37°C for 15 min, precipitated by 150 g/L sulphosalicylic acid and centrifuged and supernatant used for detection and analysis.

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Analytical Determinations For Clinical Study

Serum, HDL and LDL cholesterol, and triglycerides were determined using an auto analyzer Synchron CX7 based on enzymatic colorimetric assays. B12 and folate were determined by electrochemiluminescent immunoassay using a Roche Cobas immunoassay analyzer. The reference values in our laboratory for non-pregnant women are as follows: 191 to 663 ng/L for vitamin B12 and 4.6 to 18.7 g/L for folate.

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Vitamin Ds Role In Lowering High Blood Pressure

What is the specific role that vitamin D plays in decreasing high blood pressure? There are strong connections between where a person lives, vitamin D levels, and high blood pressure. Basically, the further you go from the equator, the higher the blood pressure. This suggests that vitamin D may protect against high blood pressure.

There are other factors which may explain why vitamin D lowers blood pressure. For example, some studies that suggest that theres a link between vitamin D and blood pressure regulation through the renin-angiotensin system. This system influences how vitamin D affects the kidneys and renal glands through a hormone produced by the kidneys called renin.

Also, parathyroid hormone levels will increase when vitamin D is low, and high PTH can raise blood pressure by increasing the effect on renin secretion.

Its thought that low vitamin D is associated with reduced sensitivity to insulin, which can raise blood pressure. The lack of vitamin D may cause blood vessel walls to thicken and stiffen, resulting in high blood pressure.

Its also possible that vitamin D isnt associated with blood pressure at all. Instead, low vitamin D levels may be linked with other high blood pressure risk factors, including consuming an unhealthy diet, lack of exercise, and obesity.

How The Non Hdl Cholesterol And Vitamin D Tests Are Done :

Vitamin D And Cholesterol (Low HDL)

If your doctor wants Non HDL cholesterol and Vitamin D tests on you, you may need to go through these tests. During the Non HDL cholesterol and Vitamin D blood tests, a pathologist will put a needle into your veins and take out a small quantity of blood. A pathologist is a physician in the medical field who thoroughly studies the causes and effects of disease. Within a few hours you will get your Non HDL cholesterol and Vitamin D Test reports by your pathologist.

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Can Vitamin D Deficiency Cause High Cholesterol

Vitamin D deficiency linked to increased risk of dyslipidemia. Higher vitamin D levels appear to be associated with higher total cholesterol levels and higher HDL cholesterol levels, according to a new study presented at the 65th Annual Scientific Session of the American College of Cardiology . 1.

How is vitamin D deficiency related to dyslipidemia?

Vitamin D deficiency linked to increased risk of dyslipidemia. Higher vitamin D levels appear to be associated with higher total cholesterol levels and higher HDL cholesterol levels, according to a new study presented at the 65th Annual Scientific Session of the American College of Cardiology . 1

High Activity High Stress

Are you training intensely for an event or competitive season? Are you really busy and on the go with work and/or kids at home? The greater stress load on your body, the greater the demand for vitamin B12 which can put drain your levels, especially when combined with a diet that doesnt contain enough of the essential vitamin.

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How Much Vitamin D Should You Be Getting

The amount of vitamin D someone needs depends on their age, as highlighted below.

Infants 0-6 months:

  • 400 IU/day for adequate intake
  • Upper level intake of 1,000 IU/day

Infants 6-12 months

  • 400 IU/day for adequate intake
  • Upper level intake of 1,500 IU/day

Children 1-3 years old

  • Recommended dietary allowance of 600 IU/day
  • Upper level intake of 2,500 IU/day

Children 4-8 years old

  • Recommended dietary allowance of 600 IU/day
  • Upper level intake of 3,000 IU/day

People 9-70 years old

  • Recommended dietary allowance of 600 IU/day
  • Upper level intake of 4,000 IU/day

People over 70 years old

  • Recommended dietary allowance of 800 IU/day
  • Upper level intake of 4,000 IU/day

Women 14-50 years old who are pregnant or lactating

  • Recommended dietary allowance of 600 IU/day
  • Upper level intake of 4,000 IU/day

That being said, other factors can affect how much vitamin D you may needâso itâs best to ask your healthcare provider what they advise for you.

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Getting Vitamin D From Sunlight

The True Risks of Low Vitamin D Levels #Vitamintips

To make vitamin D, you need sunlight on your skin. From April until the end of September its possible to get enough vitamin D by spending time outside.

For most people, you only need to be outside for short periods of time, for example around 20-30 minutes. Although the exact time isnt known because its different for different people. If you have dark skin, for example if youre of south Asian, African or African Caribbean origin, you will need longer in the sun.

You need to have some skin exposed, for example, your forearms, hands and lower legs. But you can still make vitamin D even if you sit in the shade.

Sitting inside by a sunny window doesnt count because glass filters out the UVB rays the type of light that is needed to make vitamin D.

In the UK, we dont get enough vitamin D from sunlight between October and March, because the light doesnt contain enough UVB rays. During this time, we need to rely on getting enough vitamin D from food, and possibly supplements.

The guidelines in the UK are that everyone should consider taking a vitamin D supplement in the winter, especially if youre more like to have a deficiency.

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Not Getting Enough Vitamin D

We dont need vitamin D from food or sunlight every day. But if you dont get enough over a longer period of time, you wont have enough vitamin D for good health known as vitamin D deficiency. This is very common in the UK around one in five adults and one in six children dont have enough vitamin D.

Some people are more likely to have a vitamin D deficiency than others. Supplements and eating foods which contain vitamin D can help.

How The Vitamin D And Non Hdl Cholesterol Tests Are Done :

If your doctor wants Vitamin D and Non HDL cholesterol tests on you, you may need to go through these tests. During the Vitamin D and Non HDL cholesterol blood tests, a pathologist will put a needle into your veins and take out a small quantity of blood. A pathologist is a physician in the medical field who thoroughly studies the causes and effects of disease. Within a few hours you will get your Vitamin D and Non HDL cholesterol Test reports by your pathologist.

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Low Vitamin D Linked To Metabolic Syndrome In Postmenopausal Women

Tara Haelle

Postmenopausal women with vitamin D deficiency have greater risk for metabolic syndrome than those with sufficient levels, data from a cross-sectional cohort study suggest. Levels of 25-hydroxyvitamin-D below 20 ng/mL were also linked to a greater likelihood of high triglycerides and low high-density lipoprotein cholesterol.

“These results suggest that the maintenance of adequate serum levels of 25D in postmenopausal women may reduce the risk of developing , a condition that is known to be related to cardiovascular events and mortality in this group,” write Eneida Boteon Schmitt, MD, from São Paulo State University’s Botucatu Medical School in Brazil, and colleagues.

They note, however, that the observational, cross-sectional design of the study prevents causal inferences and that unmeasured confounders may play a role in the findings. Also, as 90% of the study participants were white, the findings may not be generalizable to other races/ethnicities.

The study, in the January 2018 issue of Maturitas, included 463 women, 45 to 75 years old, who had not menstruated for at least a year, were not taking vitamin D supplements, and had a diagnosis of cardiovascular disease. The researchers measured their total cholesterol, HDL levels, low-density lipoprotein levels, triglycerides, glucose, insulin, and 25D levels.

More than half of the women without sufficient vitamin D had metabolic syndrome compared with 39.8% of women with sufficient vitamin D levels .

What Are The Effects Of Vitamin D Supplementation

Dr. Berg’s Wife Has Crazy High Cholesterol of 261..

Vitamin D supplementation may be helpful in hypercholesterolemic patients with vitamin D insufficiency who are at high risk for cVitamin D supplementation appears to have a beneficial effect in reducing serum levels of total cholesterol, LDL cholesterol, and triglycerides, but not on HDL cholesterol levels.

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Do Vitamin D Levels Affect Cholesterol

Higher vitamin D levels appear to be associated with higher total cholesterol levels and higher HDL cholesterol levels, according to a new study presented at the American College of Cardiologys 65th Annual Scientific Sessions.1

Investigators looked 13 039 adults and found that higher 25-hydroxyvitamin D was cross-sectionally and prospectively associated with higher total cholesterol and HDL cholesterol levels and lower total cholesterol-to-HDL cholesterol ratio after considering factors such as diabetes and adiposity.

We wanted to see the association of low vitamin D with low HDL cholesterol and high total cholesterol-to-HDL cholesterol ratio, but I think we were most surprised to not find an association of vitamin D deficiency with elevated triglycerides, as has been noted in other studies. This may be in part that we carefully adjusted for other confounding lifestyle variables such as physical activity and 2 measures of adiposity , said senior study author Erin Michos, MD, MHS, associate professor of medicine and epidemiology and associate director of preventive cardiology at Johns Hopkins School of Medicine in Baltimore.

Dr Michos and her colleagues measured lipids at baseline , in 1993-1994, and in 1996-1998. The mean follow-up was 5.2 years.

Diabetic Neuropathy And B

One of the potential complications of diabetes mellitus is neuropathy, also called nerve damage. Its caused by the adverse effects of high blood glucose over a long period.

The most common symptoms of diabetic neuropathy are those described above for peripheral neuropathy that often affect arms, hands, legs, and feet.

Diabetic neuropathy can also affect other body parts, including the gastrointestinal tract.

You dont have to have diabetes to develop neuropathy. Prolonged B-12 deficiency can also damage your nerves.

Whether you have diabetes or not, symptoms of neuropathy should not be ignored.

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How Vitamin B12 Deficiency Harms Health

In the body, vitamin B12 also known as cobalamin is especially vital to making red blood cells, and maintaining proper function of nerve cells. When vitamin B12 levels are low, a person can develop health problems related to red blood cells and nerve cells malfunctioning.

The most common problems related to low vitamin B12 levels include:

  • Anemia. This means the red blood cell count is low. Red blood cells carry oxygen in the blood, so anemia can cause fatigue or shortness of breath. The breakdown of faulty red blood cells can also cause jaundice.
  • Neuropathy. This means that nerves in the body are not working well. This can cause a variety of symptoms, including tingling, numbness, burning, poor balance, and walking difficulties.
  • Cognitive impairment. This means that nerve cells in the brain are not working well. This can cause memory problems, irritability, and even dementia.

You may have heard that vitamin B12 deficiency can cause pernicious anemia. But in fact, the term pernicious anemia means a specific vitamin B12 deficiency caused by the loss of a bodys ability to make intrinsic factor. The body needs intrinsic factor to absorb vitamin B12 without it, vitamin B12 levels eventually drop. This often causes anemia, but sometimes symptoms of nerve and brain problems occur first.

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Research Instruments And Data Collection Procedures

Vitamin D_image 4

An interview-based data collection approach was followed by using a structured questionnaire, followed by blood pressure and anthropometric measurements, and blood sample collection. Detailed interviews were conducted to obtain information about socio-demographic characteristics, smoking history, medical history, physical activity, sun exposure, vitamin D supplementation, and reproductive history . The study protocol was approved by the Institutional Review Board, King Saud University , and the Institutional Review Board of the Ministry of Health, Saudi Arabia . Written informed consent was obtained from participants after the purpose of the study was explained clearly, with emphasis on voluntary participation, anonymity, and confidentiality.

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Why We Need Vitamin D

Vitamin D helps you absorb calcium and phosphorus from your diet and use these minerals to keep your bones, teeth and muscles strong. This helps prevent falls as you get older.

Vitamin D may have other roles in the bodys immune system and heart health too.A lack of vitamin D can cause bone problems such as rickets in children and muscle weakness and painful or tender bones in adults.


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