How Vitamin E Slows Osteoarthritis
In 2012, another study was published investigating the effects of free radicals on cartilage degradation and the benefits of antioxidants such as vitamin E4. Bhattacharya and colleagues found that free radical activity correlated with progressive osteoarthritis. However, under the influence of vitamin E, this process was significantly slowed.
The status of various antioxidant enzymes and inflammatory markers were investigated in 40 healthy volunteers and 40 patients with osteoarthritis. The data was collected at the start of the study and three months later after a daily dose vitamin E.
The researchers found that vitamin E reduced inflammation in the joints and increased antioxidant potential. Consequently, free radicals exerted less influence on the joint. However, further studies are needed to investigate the exact effects of vitamin E and the mechanisms involved.
Best Vitamin E For Dogs
What is the best source of vitamin E for dogs? Vitamin is widely found in high quality organic dog food. Foods that contain wheat germ are said to be good sources of vitamin E. When considering the best vitamin E to give to your pets, natural sources are preferred over synthetic.
Food sources include:
- Ostrich, halibut, sardine, kidney and liver meats
- Herbal sources such as raspberry leaf, dandelion, flaxseed, oat, straw and alfalfa
Top 4 Supplements To Treat Arthritis Pain
Choosing the right supplement to ease your arthritis pain and inflammation can be confusing. Which supplements are most effective? Of the many types of supplements available in stores and online, the following 4 have been well-studied for their ability to treat arthritis pain:
Research suggests curcumin, found in the spice turmeric, has anti-inflammatory properties and has the potential to reduce arthritis pain.
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Collection Of Blood Plasma
Rats were sacrificed at the end of the study by CO2 asphyxiation. During necropsy, blood was withdrawn from all experimental animals through cardiac puncture. Blood samples were collected in vacutainer tubes containing ethylenediaminetetraacetic acid . Plasma was isolated by centrifugation . The plasma samples were stored at 80°C until further analyses.
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Theres something appealing about being able to help manage a chronic illness with so-called natural remedies like vitamins and minerals. That explains why theres no shortage of natural remedies marketed to people with rheumatoid arthritis and other forms of inflammatory arthritis.
There is a shortage, however, of solid scientific evidence to support whether or not you should take certain supplements. Will they actually help improve arthritis symptoms? Could they interact with other medications you take? Or might they potentially have negative side effects of their own?
Herbal supplements in particular concern me because theyre marketed using testimonials and not on any clinical data, says William Davis, MD, the chair of rheumatology at Oschner Health System in New Orleans and a fellow of the American College of Physicians and the American College of Rheumatology. As a physician, its my role to recommend treatments where theres a higher understanding of risks and benefits.
There are, however, certain vitamins and minerals that research shows can be an essential part of treatment for many patients with inflammatory arthritis. We asked Dr. Davis which ones you may need as part of your recommended treatment plan, as well as which natural remedies may show the most promise in helping with pain relief.
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Best Fish For Arthritis
Adding more marine life to your meals could help calm inflammation
Arthritis is for the most part a disease of inflammation. When your joints swell, turn red and feel warm to the touch, what youre witnessing and feeling are inflammatory processes in motion.
One way to calm inflammation is with medicine your doctor prescribes. Another way is to add a few key anti-inflammatory foods to your diet. Among the most potent edible inflammation fighters are essential fatty acids called omega-3s particularly the kinds of fatty acids found in fish.
Omega-3s and Inflammation
Eicosapentaenoic acid and docosahexaenoic acid are called marine fatty acids because they come from fish. What makes these omega-3 sources worthwhile menu additions for people with arthritis is their ability to inhibit inflammation. Omega-3s interfere with immune cells called leukocytes and enzymes known as cytokines, which are both key players in the bodys inflammatory response.
The marine omega-3 fatty acids nip inflammation in the bud before it ignites. They really help to tamp down inflammation in the body on a cellular level, says Kim Larson, a Seattle-based nutritionist and Academy of Nutrition and Dietetics Spokesperson.
Research finds that people who regularly eat fish high in omega-3s are less likely to develop rheumatoid arthritis . And in those who already have the disease, marine omega-3s may help reduce joint swelling and pain.
Which Fish are Best?
Farm-Raised, or Wild-Caught?
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Diet For Arthritis: Vitamins Nutrients And Supplements That Help Arthritis
Arthritis is a medical condition affecting a joint or joints, causing pain, swelling and stiffness. The two most common forms are osteoarthritis and rheumatoid arthritis. Osteoarthritis usually affects people after middle age and is characterized by gradual loss of cartilage of the joints. Rheumatoid arthritis is a chronic condition that can result in weakness, loss of mobility, and eventual destruction and deformity of the joints. It occurs when the body’s immune system destroys the synovial membrane lining the joint. Both conditions are intensified if you are overweight.
Arthritis exercises – Download free exercise PDF.
Vitamin E Oil For Dogs
Is it OK to rub vitamin E oil on my dogs skin? Dogs with dry skin can greatly benefit from the application of vitamin E. Vitamin E does not have to be taken internally to benefit your dog. While your dog is having a well-balanced diet full of vitamin E goodness, rubbing his coat with vitamin E oil or soaking him in a tub of vitamin E water will help improve his skin condition.
Vitamin E is full moisturizing properties and will protect your dogs skin from getting too dry. If possible, you can have your dog take vitamin E gel caps with food.
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Preclinical Evidence From Cellular Studies
In a model of leporine cartilage explants, investigated the effects of oxidative stress and antioxidants on cartilage matrix degradation . When the explants were treated with hydrogen peroxide and calcium ionophore, the cartilage matrix degraded, releasing proline, the major component of collagenous polypeptides, which was then detected by the researchers . Pretreatment with superoxide dismutase and catalase did not prevent the chondrocyte-mediated matrix degradation, maybe because the molecules were too large to penetrate the explants . On the other hand, vitamin E at 250 and 500 mM prevented matrix degradation more effectively than vitamin C, indicating that the process may be mediated by lipid peroxidation . This was evidenced by the observations that vitamin E also lowered malondialdehyde and hydroxynonenal-protein adducts from chondrocytes . Other inhibitors of lipid peroxidation, like butylated hydroxytoluene and deferoxamine, also prevented matrix degradation in the explants in a manner similar with vitamin E .
Is It Possible To Get Vitamin D From Food
Certain foods do contain vitamin D but the range of foods is minimal.
Foods like salmon, tuna, cheese, egg yolk and some other dairy products contain vitamin D but compared to other vitamins there isnt a very wide variety to go at. That being said, incorporating those foods mentioned will do some good.
Salmon has fantastic health benefits and is a source of vitamin D!
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Fish Oil For Arthritis
Rheumatoid arthritis is a chronic autoimmune disease characterized by pain, swelling, and joint destruction. It is caused by the overproduction of certain PUFAs that are responsible for the natural inflammatory processes in the body.
A survey in the United States found that 90% of people diagnosed with arthritis have used alternative therapies for pain reduction, which include fish oil supplements. It was found that patients who consumed fatty fish more than two times a week had lesser values of an inflammatory marker than those who consumed fatty fish less than once a month.
The benefits of fish oil are thought to be due to its high concentration of EPA and DHA, which help in reducing the inflammatory mediators in the joint space.
This helps alleviate the pain associated with rheumatoid arthritis and allows a reduction in the use of analgesics and disease-modifying drugs . The beneficial effect, though, is not immediate and takes at least 34 months to set in.
However, note that cod liver oil, in addition to being a good source of EPA and DHA, contains high amounts of fat-soluble vitamins A and D, which, when consumed at anti-inflammatory doses, may produce vitamin toxicities. Therefore, it is imperative to consult your doctor about the use and dosage of fish oil supplements.
What Is The Best Vitamin To Take For Arthritis
Also known as ascorbic acid, Vitamin c is a very powerful antioxidant that is required for hundreds of metabolic functions in the body including tissue growth and repair.
It is probably better known as a remedy for the common cold, but as far as arthritis sufferers are concerned it is vital for the production of collagen, which is a protein needed for healthy skin, bones and cartilage. It enhances the body’s ability to repair damage to cartilage, therefore an important vitamin for prevention of, and help in, soothing arthritis symptoms.
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Why People With Ra Need Vitamin D
According to researchers from the Albert Einstein College of Medicine, people who take oral steroids have a heightened risk of vitamin D deficiency. If you take corticosteroids for RA, youre twice as likely to be short on this crucial vitamin than the average person.
If you dont get enough vitamin D, your bones can become soft and brittle. This can raise your risk of bone fractures, deformities, and other problems.
For people with RA, vitamin D can have additional benefits: RA is an autoimmune disorder, and vitamin D plays a role in the immune system. People with RA also have high levels of inflammation, and vitamin D helps mediate this condition.
If you have RA, get your vitamin D levels checked regularly, and take steps to correct any nutritional deficiencies.
Rcts Of Vitamin A For Oa
A single RCT tested the efficacy of vitamin A for OA and is that of Mahmud described earlier, comparing vitamin A, vitamin E and the combination of vitamin A and E. As noted above, this trial cannot be interpreted because it failed to use either a placebo control or standard comparator treatment, and because of inadequate statistical analysis and poor reporting.
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Determination Of Total Antioxidant Capacity By Frap
The total antioxidant capacity was measured by FRAP assay as described by Benzie and Strain . This assay depends upon the reduction of ferric tripyridyltriazine complex to ferrous tripyridyltriazine form at low pH. After this reduction, the absorbance was determined at 593 nm. Ferrous sulfate was used as the standard.
Are You Getting Enough Vitamin D
Your doctor can order blood tests to determine whether youre getting enough vitamin D, but here are a few more telltale signs of a deficiency:
- Chronic pain or aches that last for weeks, similar to symptoms associated with rheumatoid arthritis
- Melancholy or depressed mood
- Osteoporosis and brittle bones
- Fatigue and weakness that doesnt seem normal
- Excessive sweating, especially on your forehead
Maintaining an adequate vitamin D level is essential in the management of rheumatoid arthritis, says Elizabeth Ortiz, MD, assistant professor of clinical medicine at the Keck School of Medicine of USC and a rheumatologist at Keck Medicine of USC. It has been shown to help with pain control and may even be beneficial in controlling inflammation and disease activity.
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Types And Sources Of Omega
There are three major omega-3 fatty acids:
- Eicosapentaenoic acid
- Docosahexaenoic acid
- Alpha-linolenic acid
EPA and DHA are macronutrients not synthesized in the body but are concentrated in large amounts in the flesh of marine animals.
Plants are the major source of ALA, which can be converted to EPA and DHA in the liver but in limited quantities. Thus, it is more efficient to increase the intake of EPA and DHA through the diet or supplements, upon the recommendation of your doctor.
Plant sources of omega-3 fatty acids:
- Fish liver oil such as cod liver oil, which also contains vitamins A and D
- Krill oil
- Algal oil
- Flaxseed oil, a source of ALA
Note: The American Heart Association recommends eating 2 servings of fatty fish per week. Approximately 8 oz of fatty fish provides 14 g of EPA+DHA.
Using Vitamins To Your Advantage
There isnt a specific diet for osteoarthritis, but certain compounds seem to target the joints more than others. Recent research has returned some welcome results on how a few common protective vitamins can directly impact your skeleton, with benefits ranging from fewer bone marrow lesions to a stronger bone and joint network.
These findings are good news for OA patients who want some more control over their disease management. But while a dietary shift may be an easy and safe route to better bone health, its not a cure-all and in some cases, increasing your vitamins can work against you.
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Supplements For Arthritis And Joint Pain
Arthritis Joint Pain: Supplements and Herbs
Glucosamine helps keep the cartilage in joints healthy and may have an anti-inflammatory effect. Natural glucosamine levels drop as people age.
Chondroitin is often used with glucosamine as an osteoarthritis treatment. Researchers found that chondroitin appeared to reduce pain, increase joint mobility, and decrease the need for painkillers.
The research into the effectiveness of glucosamine and chondroitin for arthritis symptoms is mixed. Doctors do not recommend these supplements but are not opposed to their use if a patient gets relief from using them. Doctors recommend against using glucosamine hydrochloride.
Omega-3 Fatty Acids
Omega-3 fatty acids, found in fish oil and other foods, encourage the body to produce chemicals that help control inflammation. This supplement may help ease stiffness caused by inflammation in people with rheumatoid arthritis, but more research is needed.
Curcumin and/or Boswellia serrata
Rcts Of Vitamin E For Inflammatory Arthritis
Serum vitamin E levels more than doubled over 12 weeks in the treatment group in a trial in RA, but Edmonds found no significant differences between groups in three clinical outcomes regarded by the authors as indicators of inflammation. There were significant differences favouring vitamin E in patient recorded morning pain, evening pain and pain after a chosen activity, but these analyses used one-tailed tests. A re-analysis confirmed significant differences favouring the vitamin E group for morning and evening pain but not for pain after a chosen activity. It is not clear how daily patient data for the pain scales were gathered and which of these data were used in the analysis at 12 weeks. Differences between groups in patient global assessments failed to reach significance while investigator assessments significantly favoured vitamin E. Even so, according to investigator global assessments, 60% of patients showed no change or got worse. Baseline data indicate that the vitamin E group had more severe RA than controls. The authors concluded that vitamin E has analgesic but not anti-inflammatory effects. The latter conclusion was supported by haematological and biochemical data gathered during the study.
The second RCT comparing vitamin E with placebo is that of JÃ¤ntti described earlier. The abstract available provides no assessable data but the authors concluded there was no clear effect of vitamin E on RA.
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Trials For Rheumatoid Arthritis
Three of the four trials in this review article investigated the potential role of vitamin E in treating rheumatoid arthritis, while the fourth studied the effectiveness of selenium ACE treatment.
- In the first trial , there was no significant difference between participants on 1,200 mg per day vitamin E supplements or a placebo in morning stiffness, number of swollen joints and degree of joint tenderness, but there was a significant difference in pain reduction in favour of participants taking vitamin E.
- In both the second trial and the third trial , there was no significant difference between participants allocated 1,200 mg a day vitamin E supplements or participants given 150 mg diclofenac a day in all aspects of disease severity at the end of the trial.
- In the fourth trial , there was no significant difference between participants who received selenium ACE supplements or participants on a placebo in all aspects of disease severity at the end of the trial.
A trial of low quality. Results of this trial were given a lower weighting when we came to our conclusion about the compound.