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Since B12 is a water-soluble vitamin, its generally considered safe, even at high doses. No Tolerable Upper Intake Level has been established for B12, due to its low level of toxicity. UL refers to the maximum daily dose of a vitamin unlikely to cause adverse side effects in the general population.
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Can Vitamin D Prevent High Blood Pressure
Maybe the evidence is not entirely clear. Though the role of vitamin D in blood pressure and heart health has been the topic of considerable investigation since at least the mid-1980s, the conclusions of the research studies are difficult to interpret. While it is known that both the blood vessels and the heart have large numbers of vitamin D receptors which means that vitamin D is providing some function in regulating these issues figuring out what these receptors do has been difficult. Studies on the action of vitamin D sometimes appear to contradict each other, and sometimes they yield data that cannot be accurately interpreted.
One study found that administering vitamin D to older adults with existing high blood pressure caused both the systolic blood pressure and diastolic blood pressure to decrease. The same study also found that giving both vitamin D and calcium together caused even larger decreases in both systolic and diastolic blood pressure. These data suggest that vitamin D and calcium somehow work together to cause a reduction in blood pressure and that high levels of calcium promote the blood pressure reducing action of vitamin D. Curiously, though, when the study participants were examined more carefully, it was found that this only worked in people who had relatively high calcium levels to start. In people who had low calcium levels at the beginning, neither vitamin D nor vitamin D plus calcium was very effective at lowering blood pressure.
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Why We Need Vitamin D
Vitamin D helps you absorb calcium and phosphorus from your diet and use these minerals to keep your bones, teeth and muscles strong. This helps prevent falls as you get older.
Vitamin D may have other roles in the bodys immune system and heart health too.A lack of vitamin D can cause bone problems such as rickets in children and muscle weakness and painful or tender bones in adults.
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What Studies Say About Vitamin D And Blood Pressure
What does the scientific evidence tell us about the link between vitamin D and lower blood pressure? Some research suggests that taking vitamin D3 supplementation can help reduce lower blood pressure. For instance, a randomized, placebo-controlled study published in the American Journal of Hypertension in 2012 found that vitamin D3 supplementation significantly decreased systolic and diastolic blood pressure. Researchers examined the effect of 3,000 IUs of vitamin D3 per day in 130 patients with hypertension.
Other studies suggest that vitamin D, including the active or inactive form , are both ineffective for lowering blood pressure. However, some of these studies were shorter and used smaller doses of vitamin D. These negative studies were also not published in recognized scientific journals.
The Mechanisms Of Vitamin D In Regulation Of Blood Pressure
Vitamin D receptor is present in thirty-six tissues and also at least 10 tissues possess 1-hydroxlyase besides the renal proximal tubule. These facts mean the cells in various tissues need vitamin D during their biological actions. Several mechanisms have been suggested to be involved in the pathogenesis of hypertension,.
Inappropriate activation of renin-angiotensin-aldosterone system has been widely known as the important factor contributing to the development of hypertension. For that reason, blockers of the RAAS, such as renin inhibitors, angiotensin-converting enzyme inhibitors, angiotensin II type 1 receptor antagonists, and mineralocorticoid receptor antagonist are very important drugs in the treatment of hypertension. Surprisingly, vitamin D, the sunshine hormone was shown to regulate the RAAS at the clinical, pathophysiological and molecular levels in animals and human studies,.
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If you are one of the 95 million Americans with high cholesterol, you might like the idea of taking a natural supplement to lower your levels. Two possible pills that lower cholesterol levelsred yeast rice and niacindont play well together. Doubling up doesnt increase the benefits and may be harmful to the liver, says Todd Sontag DO, a family medicine specialist with Orlando Health Physician Associates in Florida. When prescription cholesterol-lowering drugs are added to the mix, your risks can increase. Be sure youre aware of niacin flush and what you can do about this potential side effect.
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People Most At Risk Of Vitamin D Deficiency
Some people dont have enough vitamin D. This could be because their skin isnt exposed to enough sunlight, or because of health problems or higher needs for vitamin D.
For example, if:
- you dont go outdoors often, for example if you are housebound, in hospital or are disabled and less able to get about
- you wear clothes which cover most of your skin when you go outside
- you have dark skin, for example if youre from an African, African-Caribbean or south Asian background as you need more sunlight to make enough vitamin D
- you wear sunscreen most or all of the time
- you need more vitamin D, babies, young children and pregnant and breastfeeding women need more vitamin D
- you are an older adult, as older people cant make as much vitamin D
- you have a health problem or youre taking certain medications which change the way vitamin D is controlled in the body, such as Crohns disease, coeliac disease, and some types of liver and kidney disease.
- you are very overweight, a there is some evidence to suggest that people who are very over weight are more likely to lack vitamin D
- you eat very few foods that contain vitamin D.
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The hormone, estrogen, is a common ingredient in birth control pills, and taking it for a long time has been shown to raise your blood pressure. This is a definite no-no if you have uncontrolled high blood pressure. Thankfully, there are contraception options that have just progestin or no hormones at all , so keep this in mind if you have been diagnosed with hypertension and are looking to prevent pregnancy.
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Vitamin D And Statins
There has been some debate around whether statins could stop us making enough vitamin D because statins lower cholesterol. In reality, we have more than enough cholesterol to make vitamin D, even if you take statins. Its more important to make sure youre getting enough time in sunlight or getting enough vitamin D from foods or supplements.
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