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Is Vitamin D Good For Osteoarthritis

Vitamin D And Articular Cartilage

Vitamin D and Arthritis! New study!

Recent evidence suggests that the role of vitamin D in the progression of OA is promising. Articular cartilage degenerates in OA patients due to a homeostatic imbalance in which catabolic processes overrule anabolic processes. As a result of this reaction, articular cartilage becomes hypertrophic and eventually deteriorates. Several studies have shown that VDRs are upregulated on damaged cartilage. Tetlow and Woolley47 showed that VDR expression is increased in areas of erosion in patients with late-stage rheumatoid arthritis. The same research group48 and Orfanidou et al39 showed similar results in patients with OA. When vitamin D binds to VDRs, a signaling cascade effect occurs. Tetlow et al48 demonstrated that chondrocytes expressed increased levels of MMPs 1, 3, and 9 in vivo. This leads to degradation of bone at increased rates.30 VDRs also signal increase in fibroblast growth factor 23, caspase 9, and extracellular signal-regulated kinase 1/2. When VDR is inhibited, downregulation occurs.39 The upregulation of vitamin D signaling in an arthritic joint is the bodys response to joint degeneration through an attempt to spread joint contact pressures through new bone formation in the form of osteophytes, but it is unclear whether this is a positive or ultimately detrimental response. Future research should aim to investigate the extent and severity of these actions and their implications on the development and progression of OA in relation to articular cartilage.

What Supplements Are Good For Arthritis

As well as having a healthy, balanced diet, getting additional nutrients from food supplements may help if you have arthritis.

  • Omega-3 fatty acids for inflammatory arthritis.
  • Vitamin E.
  • Glucosamine sulphate and chondroitin for osteoarthritis.
  • Exclusion diets.
  • Are they safe?

Herein, what is the best supplement for joint pain?

Here are six common supplements for arthritis and the evidence of their effects on joint pain.

  • Glucosamine.

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Bone Mineral Disease Management In Ra Patients And Others

Despite our cautionary notes, we recognize that the prescription of calcium and vitamin D supplements to those at high risk of osteoporosis is warranted according to current recommendations . RA, like age, lifestyle, and hormonal and nutritional factors, should be considered a risk factor for osteoporosis. The presence of one or more of these risk factors may lead to measurement of bone mineral density by dual x-ray absorptiometry , and should result in advice to the patient on adequate calcium and vitamin D intake , exercise, and lifestyle modification. Intervention for the prevention of bone loss should be considered when the DXA T score is less than approximately â1.0 to â1.5 in the presence of osteoporosis risk factors. This intervention may include vitamin D and calcium supplementation as well as lifestyle advice.

Presently the decision to treat a patient with vitamin D and calcium supplements is commonly based on simple osteoporosis risk factors and DXA results rather than serum 25D levels. This practice may be analogous to giving statins to individuals at high cardiovascular risk irrespective of their cholesterol level. Whether measurement of serum 25D helps to further improve stratification for risk of osteoporosis remains to be determined, although there is some evidence that a sizable proportion of postmenopausal women with osteoporosis are not necessarily vitamin D deficient .

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What Does Osteoarthritis Do To Your Body

Once our cartilage starts to wear down, other things start to happen to our joints. The bones can rub together, creating inflammation and pain.

This is why so many people develop Osteoarthritis in their hands or knees because those joints tend to bear the most weight.

If you have Osteoarthritis, your remaining cartilage has less cushioning, which makes it easier for your bones to rub together. This causes the bones to be damaged, which eventually leads to joint stiffness and pain.

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Vitamin D Prevents The Progression Of Osteoarthritis

Natural Supplements For Osteoarthritis

A study published in Clinical Orthopaedics and Related Research assessed the role of vitamin D in knee osteoarthritis.

When the patients were given vitamin D supplements, it was observed that vitamin D had a significantly beneficial effect in improving the characteristics of osteoarthritis-like knee pain and joint function.

Another study published in The Journal of Nutrition reported that people who are deficient in vitamin D are at a higher risk of developing knee osteoarthritis.

A study published in BioMed Central assessed the benefits of vitamin D supplementation to control knee osteoarthritis. Vitamin D supplements reduced the loss of cartilage, knee pain, and other structural abnormalities.

What does this mean? Research shows that supplementation with vitamin D in osteoarthritis patients relieves symptoms and helps control disease progression.

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Articular Cartilage And Osteoarthritis

Macroscopically, the earliest sign of articular cartilage degeneration is due to fibrillation of its superficial layers.10 As the disease progresses, the superficial surface irregularities form clefts, the articular surface roughens, and the fibrillations extend deeper into the cartilage until the fissures invade the subchondral bone.10,50 As the cartilage fissures deepen, the articular cartilage tears, and fragments are released into the joint space, leading to possible irritation.10 Eventually, enzymatic degradation of the matrix decreases the cartilage, leading to loss of articular cartilage and ultimately the presentation of pain as a symptom of OA.10,50

The third stage occurs when the decline in the chondrocytic anabolic and proliferative response leads to progressive loss of articular cartilage.10 Eventually, the articular cartilages anabolic response declines, and the imbalance between chondrocyte synthetic activity and degradative activity leads to progressive thinning of articular cartilage.32 The thinning and ultimate loss of articular cartilage leads to the clinical syndrome of OA, characterized by joint pain and loss of joint function.10

Sunlight And Vitamin D

This is a tricky solution because you dont want to increase your risk of skin cancer. But if you expose your skin to sunlight for a brief period daily, a compound in your skin will convert ultraviolet B radiation into vitamin D. Even sitting by an open window for several minutes can boost your intake. People with darker skin tones wont burn as easily, but they also do not absorb as much vitamin D as people with lighter skin.

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Effect Of Vitamin D3 And Virgin Coconut Oil On Cartilage Degeneration Inflammation And Functional Abilities In Early Knee Osteoarthritis

Monal Velangi, Subhadra Mandalika, Surendra Shukla, Vandana Pradhan


Background:Knee osteoarthritis is a chronic, degenerative knee joint disorder associated with inflammation, pain, stiffness, and reduced functional abilities, thereby impacting the patients quality of life. The prevalence of KOA is growing rapidly in India and around the globe, even in younger populations. Vitamin D plays a crucial role in musculoskeletal health and deficiency of this vitamin is highly prevalent across the age groups impacted by KOA. Consumption of vitamin D rich foods along with functional foods possessing antioxidant and analgesic properties needs to be explored as a potentially novel, low cost dietary strategy for the prevention and management of chronic musculoskeletal disorders such as KOA.

Objective:To assess the effect of vitamin D3 and Virgin Coconut Oil supplementation on vitamin D3 status, cartilage degeneration, inflammatory status, and functional abilities in early KOA.

Supplementation of vitamin D3 along with VCNO could be an effective strategy for delaying the progression of KOA by reducing cartilage degeneration, inflammation and pain, as well as improving functional abilities. Thus, simultaneous improvement of vitamin D3 status and oxidative stress should be considered in early KOA management. Non-conventional antioxidant and anti-inflammatory functional foods such as VCNO could be further explored.

Vitamin D Has Potential Benefits For People With Osteoarthritis

Antioxidants and Vitamin C for Osteoarthritis

medwireNews: Vitamin D intake is inversely associated with cartilage degeneration among patients with osteoarthritis , and supplementation may have a protective effect, suggests an analysis of data from the Osteoarthritis Initiative.

In the cross-sectional part of their study, Gabby Joseph and colleagues found a significant inverse association between self-reported dietary vitamin D intake and cartilage degeneration among 1785 patients with a KellgrenLawrence score of 3 or lower in the right knee.

Specifically, higher vitamin D intake was significantly associated with a reduction in cartilage WORMS score a modified semi-quantitative whole-organ magnetic resonance imaging score, where lower scores indicate less degeneration with an estimated drop of 0.24 points for each standard deviation increase in vitamin D.

Moreover, daily vitamin D supplementation was significantly associated with lower cartilage WORMS score in the medial femur in the cross-sectional analysis.

The researchers also demonstrated a longitudinal association between vitamin D supplementation and reduced joint degeneration over 4 years of follow-up among individuals who took supplements consistently. This association was dose-dependent, with 300 IU taken at least 46 days per week being the smallest dose and lowest frequency to show a significant inverse association with WORMS progression.

The researchers note that their study was limited by its observational design and self-reported vitamin intake.

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Vitamin D Osteoarthritis And Pain



This years theme focuses on increasing the awareness of clinicians, scientists, and the public of our growing pain knowledge and how it can benefit those living with pain.

Osteoarthritis is a degenerative condition of joints which gets worse over time. It is the leading reason for knee and hip replacement surgery about 1.8 million Australians were diagnosed with OA in 2011-12.

A new study has set out to determine if vitamin D might be a key moderator of the relationship between obesity on knee pain and function in people with OA. Heres what they report people with knee osteoarthritis who were obese but had healthy vitamin D levels were less disabled than people who were obese individuals but had insufficient vitamin D levels. The authors conclusion that vitamin D levels are significantly associated with pain and dysfunction in obese people with knee OA.

Interesting, easy, simple and clear right? Well interesting yes, but easy simple and clear? Perhaps not. This study was a secondary analysis of data that came from a much larger study that focused on racial/ethnic differences in pain and limitations among people with OA. The primary study doesnt appear to have been designed with this secondary analysis in mind there is no information about level of physical activity , amount of daily sun exposure , and diet .

From Roger Fillingim senior author and past President of the American Pain Society:

Is Vitamin D Good For Arthritis

Several scientific studies have identified a link between low vitamin D level and rheumatoid arthritis, and it is common for those with rheumatoid arthritis to have a vitamin D deficiency. Vitamin D receptor gene research reveals an association with RA susceptibility and severity.

Studies looking at vitamin D and rheumatoid arthritis have suggested that having higher levels of vitamin D may help prevent RA onset. A study that followed 29,368 women over 11 years found that greater intake of vitamin D was inversely associated with risk of developing rheumatoid arthritis.

Research also shows that lower serum vitamin D is associated with increased rheumatoid arthritis disease activity, pain and functional disability. One study of 1,191 RA patients found that lower levels of vitamin D were correlated with more severe disease activity and disability as measured by the Health Assessment Questionnaire Disability Index, Disease Activity Score , and Mobility Activities of Daily Living Score. Another study comparing 50 RA patients and 50 controls found that 84% of RA patients were vitamin D deficient versus only 34% of controls. Additionally, in this study vitamin D level was correlated to disease severity, with patients who had lower vitamin D levels having higher disease activity.

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Bone Health Is Important

Dr Christine Haseler, a GP with a special interest in arthritis, says: The risk with arthritis is that you may not be mobile, so youre less likely to be spending long periods of time outdoors and topping up your vitamin D levels in the sun.

Vitamin D is essential for bone health. With osteoarthritis, especially as you get older, you may be more likely to be frail and prone to falling. If your bone health isnt good and you fall and fracture your hip, thats very serious.

If youve had inflammatory arthritis throughout your life and if it has been persistent you may have had times without weight-bearing exercise. You may also have been on steroids, and both can lead to thinner bones and osteoporosis. Preventing thinning of the bones means you have some protection if you get into difficulty.

Why People With Ra Need Vitamin D RheumaRelief

According to researchers from the Albert Einstein College of Medicine, people who take oral steroids have a heightened risk of vitamin D deficiency. If you take corticosteroids for RA, youre twice as likely to be short on this crucial vitamin than the average person.

If you dont get enough vitamin D, your bones can become soft and brittle. This can raise your risk of bone fractures, deformities, and other problems.

For people with RA, vitamin D can have additional benefits: RA is an autoimmune disorder, and vitamin D plays a role in the immune system. People with RA also have high levels of inflammation, and vitamin D helps mediate this condition.

If you have RA, get your vitamin D levels checked regularly, and take steps to correct any nutritional deficiencies.

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How Do We Get Vitamin D

The main source is sunlight our bodies create vitamin D when bare skin is exposed to ultraviolet B rays.

During spring and summer, most peoples bodies can make all the vitamin D they need from a balanced diet and being out in the sun for short periods every day, without sunscreen and with some skin uncovered.

The ideal amount of time to spend outside isnt known, as it varies between people and depends on how much sunshine is available but be careful not to burn. Know whats right for you it may be just a few minutes in the sunshine if youre pale. Cover up and/or use sunscreen if youre staying out longer.

Dr Haseler recommends combining sun exposure with exercise.For bone health, the best activity is walking, with as many aids as you require, she says. Its weight bearing, it gets your joints moving, it exposes you to sun and meeting people, and it can be done at various levels of disability.”

Vitamin D And Inflammation

Vitamin D is a key immunoregulator in the reduction of inflammation, and it has been shown to exert influence on T and B lymphocytes, macrophages, and dendritic cells.18 VDRs are present in immune cells, and when vitamin D binds to VDRs, VDREs are activated. Activation of the VDREs in the promoter region of cytokine genes blocks transcription of nuclear transcription factors such as NF-AT and NF-B.18 This interference blocks the cellular response to TNF- and IL-1 and allows for the upregulation of IL-10.7 A recent study on vitamin Ddeficient IL-10 knockout mice with inflammatory bowel disease showed that when mice were given vitamin D, their inflammatory bowel disease was mitigated due to the effect of vitamin D on TNF-.54 In a murine colitis model, increase in IL-10 production by 1,252D3 allowed for Treg induction.12 Because of its anti-inflammatory nature, vitamin D is sometimes used as a medication for patients with chronic diseases such as rheumatoid arthritis, multiple sclerosis, and systemic lupus erythematous.37 Further investigation, however, is needed to more fully understand the specific mechanisms by which vitamin D acts to reduce inflammation.

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Vitamin D And Your Health

Vitamin D is called the sunshine vitamin for good reason. Not only does your body make vitamin D when your skin is exposed to the sun, but we also know vitamin D can ward off many health problems.

Vitamin D is a naturally occurring compound that regulates the bodys use of calcium and phosphorus. Its crucial for the formation of bone and teeth.

Because vitamin D is so important to bone growth, some researchers have wondered if supplements can help joint pain.

One study found that patients living with chronic pain who were deficient in vitamin D were the most likely to benefit from taking vitamin D supplements. However, more information is needed to determine whether vitamin D supplements can help everyone living with chronic pain.

Another study predicted that adults with a vitamin D deficiency who are older than 50 are more likely to develop pain in their hip and knee joints. The study also noted that the pain is more likely to get worse if the deficiency isnt treated.

A looked at vitamin D levels in people who have rheumatoid arthritis , an autoimmune condition that causes the body to attack its joints. The study found that most of the participants had low vitamin D levels.

The researchers concluded that the low vitamin D levels were a complication of RA. Other have concluded that people with RA have low vitamin D levels from their corticosteroid medications.

However, a

Tuna fish, canned in water, drained, 3 ounces40

What Is Gluten Free

Supplements for osteoarthritis and more!

With gluten-free diets getting more and more attention these days, you may wonder if going gluten-free would help reduce your psoriasis symptoms.

The jury is still out on eliminating gluten â a complex protein found in wheat, barley and rye. In a small number of cases, eliminating gluten can lead to improvements. However, following a gluten-free diet, which is very restrictive, is a major commitment. Itâs not a step you should take unnecessarily.

You should discuss dietary modifications, such as following a gluten-free diet, with your health care provider prior to making any diet adjustments.

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What Admin Of Vitamindwiki Is Doing About His Early Indications Of Osteoarthritis

During Spring/Summer of 2014 I got sharp pain below both knees – which my Dr. diagnosed as early indication of OA.Tried a shotgun of 7 solutions and the pain went away for several weeksStopped all solutions and the pain returned in a few days Restarted with just a subset of solutions – and have had no pain at all for the past 10 daysCurrent solutions are

Vitamin D, race, and experimental pain sensitivity in older adults with knee osteoarthritis.

Arthritis Rheum. 2012 Dec 64:3926-35. doi: 10.1002/art.37687.

Association between serum vitamin D deficiency and knee osteoarthritis

Int Orthop. 2011 Nov 35:1627-31. doi: 10.1007/s00264-010-1186-2. Epub 2010 Dec 30. full text online

Serum levels of vitamin D, sunlight exposure, and knee cartilage loss in older adults: the Tasmanian older adult cohort study.

Arthritis Rheum. 2009 May 60:1381-9.CONCLUSION: Sunlight exposure and serum 25D levels are both associated with decreased knee cartilage loss . This is best observed using the whole range of 25D levels rather than predefined cut points and implies that achieving vitamin D sufficiency may prevent and/or retard cartilage loss in knee OA. PMID: 19404958 for full article

Knee joint narrowing was found to be associated with people with low levels of vitamin D

graph from previous article

Association of low dietary vitamin K intake with radiographic knee osteoarthritis in the Japanese elderly population: dietary survey in a population-based cohort of the ROAD study.


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