No Difference In Pain Knee Cartilage Between Groups
After two years, vitamin D levels had increased by an average of 15 ng/mL in the group taking vitamin D, while the group taking the placebo only saw an increase of 1.8 ng/mL. At the start of the study, the average level in both groups was 22.3 ng/mL.
Pain scores dropped by about 2.14 points in the vitamin D group, compared with 1.2 points among patients who were taking the placebo — a difference so small it could be due to chance. Pain was assessed using a 20-point scale in which higher scores mean worse pain. Similarly, there were no substantial differences in knee cartilage volume and thickness between those people taking vitamin D and those taking placebo, the researchers say.
Vitamin D Can Improve Healing And Prolotherapy Treatments
In the Journal of Prolotherapy, Margaret E. Taylor, MBBS, BSC, FACNEM, wrote:
- People who heal well obviously differ in some important way from those who we see with chronic non-healing lesions. The distinguishing feature is primarily the effectiveness of the healing cascade. Unless the factors contributing to this are considered, the outcome of Prolotherapy will also be affected. Research shows the most important nutrients for the generation of new collagen for healing are protein, vitamin C, zinc, copper and manganese-all cofactors for various enzymes in collagen generation and stability. Nutrition in modern societies is shown to be inadequate in many of these areas and can easily be corrected.
- Malabsorption is also a cause of poor healing and musculoskeletal difficulties, and undetected celiac disease is common in our patients. Chronic widespread pain is similar but a separate entity, and thyroid and vitamin D deficiency need to be considered.
- Unexplained musculoskeletal pains are often due to vitamin D deficiency as well as deconditioning syndrome. . Pains of this type are a recognized symptom of osteomalacia which is diagnosed by tests for calcium, vitamin D and parathyroid hormone. Supplementation with vitamin D for 1 to 2 months has been shown to normalize muscle strength and pain in patients with myopathy.
- In 139 patients with muscle pain, 74% were vitamin D deficient, and 90% of those improved with vitamin D.
How Do We Get Vitamin D
The main source is sunlight our bodies create vitamin D when bare skin is exposed to ultraviolet B rays.
During spring and summer, most peoples bodies can make all the vitamin D they need from a balanced diet and being out in the sun for short periods every day, without sunscreen and with some skin uncovered.
The ideal amount of time to spend outside isnt known, as it varies between people and depends on how much sunshine is available but be careful not to burn. Know whats right for you it may be just a few minutes in the sunshine if youre pale. Cover up and/or use sunscreen if youre staying out longer.
Dr Haseler recommends combining sun exposure with exercise.For bone health, the best activity is walking, with as many aids as you require, she says. Its weight bearing, it gets your joints moving, it exposes you to sun and meeting people, and it can be done at various levels of disability.
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Data Synthesis And Analysis
Data were pooled using random-effects model. As the included trials used different scales to assess the same outcome, standardised mean differences were calculated for continuous data, and risk ratios were used for dichotomous data with their 95% CIs. To facilitate interpretation of estimated treatment effects, we considered ES up to 0.3 as small, between 0.3 and 0.8 as moderate, and greater than 0.8 as large effects. A threshold of 0.37 standardised units was defined as the minimum clinically important difference , which was based on the median MCID found in recent studies in patients with OA. We considered the effects as clinically important if ES and 95%CI exceeded our prespecified MCID threshold of 0.37. The effects were considered unclear if clinically important when the 95%CI crossed this threshold, and statistically significant but clearly not clinically important when the 95%CI was below the MCID but above the null effect line. If the 95%CI crossed the null effect line, supplements were considered ineffective.
Efficacy Of The Intervention
WOMAC
The total score of the WOMAC was evaluated in the 28 articles reviewed. There were 1404 cases in the intervention group and 1360 in the control group. The mean follow-up duration of patients was 17.4 weeks. There was a significant heterogeneity between studies . Based on the meta-analysis results, it was observed that the Pooled Standardized Mean Difference between the intervention and control groups was 0.23 units . Figure shows the forest plot of the combination of results. Results of subgroup analysis according to the supplementation duration showed that the pooled effect size in studies with< 10 months as short term, 1020 months as medium term and> 20 months as long term supplementation duration were 0.05, 0.27 and 0.36, respectively. Figure shows the forest plot of the subgroups by the supplementation duration.
Figure 4
Forest plot presenting the standardized mean difference and 95% confidence interval for the impact of nutraceutical supplementation on WOMAC total score.
Figure 5
Forest plot presenting the impact of nutraceutical supplementation on WOMAC total score .
WOMAC
Figure 6
Forest plot presenting the standardized mean difference and 95% confidence interval for the impact of nutraceutical supplementation on WOMAC pain score.
Figure 7
Forest plot presenting the impact of nutraceutical supplementation on WOMAC pain score .
WOMAC
Forest plot presenting the impact of nutraceutical supplementation on WOMAC stiffness score .
WOMAC
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Vitamin D Can Help Just Dont Ask It To Do What It Cant
As the above research points out, vitamin D does have a place in helping a patient with knee osteoarthritis. Vitamin D supplements are readily available and food rich in vitamin D are plentiful. These include salmon, herring and sardines, for non-fish lovers spinach and kale. Of course, sunshine helps a lot too.
A study in the Orthopaedic Journal of Sports Medicine from Creighton University School of Medicine concludes this way, and it is a good way to conclude our article:
Vitamin Dsufficient patients have a lower risk of developing osteoarthritis, and vitamin D sufficiency and supplementation decrease articular cartilage degeneration radiographically . Some studies have investigated the effect of vitamin D on osteoarthritis progression and pain management however, while there is no general consensus on the effects of vitamin D on osteoarthritis, some results seem promising. Vitamin D supplementation may be a safe method to treat and prevent osteoarthritis, but future research is required to define the specific pathway and ultimate efficacy.
> > > Breaking: Discover The 12
If your joint pain is caused by a sports injury or a serious condition, visit a doctor as soon as possible. Sometimes, joint pain is referred by other parts of the body. For example, a slipped disc in the back can cause leg pain, a condition known as sciatica. So, its important to visit a doctor as soon as possible. You can take a medication that will relieve your symptoms. Is Vitamin D Good For Osteoarthritis
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Vitamin D Benefits: Avoid Improve Arthritis Symptoms
Did you know vitamin D can help improve arthritis symptoms? Heres another fact: if someone does not already have arthritis, they may be able to avoid it by getting enough vitamin D.
Vitamin D is critical for overall health. For one, it helps with calcium absorption, which in turn helps the body develop and maintain healthy bones. It also reduces inflammation and plays a role in regulating the immune system, so the body is better able to ward off sickness and disease, including arthritis.
Getting the recommended allowance of vitamin D can be challenging. In fact, an estimated three-fourths of Americans dont get enough of it. Vitamin D deficiency symptoms include chronic pain, digestive issues, frequent infections and depression.
Vitamin D Impacts Arthritis
Researchers have different theories as to how vitamin D impacts arthritis. For instance, some think it has a direct impact on the joints, while others believe it is more about its effect on the immune system. A few others are still not convinced there is a solid link between the two.
Regardless of these differing opinions, many researchers agree that there is a connection between vitamin D and arthritis. There is substantial evidence to back up their claims. For example:
How to Boost Vitamin D Intake
Even though it can be hard to get enough vitamin D, the good news is there are three ways you can get it: through your skin, from certain foods and from supplements.
Association Between Serum Levels Of 25
Rheumatology doi: 10.1093/rheumatology/ket132 Yuelong Cao 1,2, Tania Winzenberg 1, Kay Nguo 1, Jianhao Lin 3, Graeme Jones 1. and Changhai Ding 1,41 Menzies Research Institute Tasmania, University of Tasmania, Hobart, Australia,2 Research Institute of Orthopedics, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China,3 Institute of Bone and Joint, Peking University Peoples Hospital, Peking, China and4 Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Australia. Correspondence to: Changhai Ding, Menzies Research Institute Tasmania, University of Tasmania, Private Bag 23, Hobart, Tasmania 7000, Australia. E-mail: Submitted 25 October 2012 revised version accepted 21 February 2013
Objective. To systematically review the evidence for association between serum 25-hydroxyvitamin D D) and OA and the effect of vitamin D therapy on OA.
Methods. An English Medline, EMBASE and Cochrane Library search for vitamin D and OA from January 1980 to June 2012 was performed. Randomized controlled trials , cohort, casecontrol and cross-sectional studies in adults were included. The methodological quality of the selected studies was assessed and a best-evidence synthesis was used to summarize the results due to the heterogeneity of the studies.
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Top 4 Supplements To Treat Arthritis Pain
Choosing the right supplement to ease your arthritis pain and inflammation can be confusing. Which supplements are most effective? Of the many types of supplements available in stores and online, the following 4 have been well-studied for their ability to treat arthritis pain:
Research suggests curcumin, found in the spice turmeric, has anti-inflammatory properties and has the potential to reduce arthritis pain.
Sunlight And Vitamin D
This is a tricky solution because you dont want to increase your risk of skin cancer. But if you expose your skin to sunlight for a brief period daily, a compound in your skin will convert ultraviolet B radiation into vitamin D. Even sitting by an open window for several minutes can boost your intake. People with darker skin tones wont burn as easily, but they also do not absorb as much vitamin D as people with lighter skin.
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Vitamin D And Inflammation
Vitamin D is a key immunoregulator in the reduction of inflammation, and it has been shown to exert influence on T and B lymphocytes, macrophages, and dendritic cells.18 VDRs are present in immune cells, and when vitamin D binds to VDRs, VDREs are activated. Activation of the VDREs in the promoter region of cytokine genes blocks transcription of nuclear transcription factors such as NF-AT and NF-B.18 This interference blocks the cellular response to TNF- and IL-1 and allows for the upregulation of IL-10.7 A recent study on vitamin Ddeficient IL-10 knockout mice with inflammatory bowel disease showed that when mice were given vitamin D, their inflammatory bowel disease was mitigated due to the effect of vitamin D on TNF-.54 In a murine colitis model, increase in IL-10 production by 1,252D3 allowed for Treg induction.12 Because of its anti-inflammatory nature, vitamin D is sometimes used as a medication for patients with chronic diseases such as rheumatoid arthritis, multiple sclerosis, and systemic lupus erythematous.37 Further investigation, however, is needed to more fully understand the specific mechanisms by which vitamin D acts to reduce inflammation.
Vitamin D Benefits In Lupus
Lupus is an autoimmune disease that occurs when the immune system attacks its own cells.
People who are suffering from this disease are asked to avoid the sun because the rays of the sun can cause rashes and also worsen the disease.
This can lead to a deficiency in vitamin D which can cause many other chronic diseases in the joints, skin, lungs, brain, and heart.
Patients suffering from lupus disease tend to have more fractures and bone and joint diseases because of a lack of vitamin D.
In this study, it was seen that patients with arthritis have a higher level of homocysteine, lower bone mineral density, and more fractures.
This increase in homocysteine increases heart problems. This makes the consumption of vitamin D supplements a necessity.
A study published in Lupus assessed the level of vitamin D in patients suffering from lupus but have not received any treatment.
It was observed that if patients do not receive any treatment for lupus, they have a low level of vitamin D which increases the level of IL-17 and IL-23 .
Another study published in Integrative Medicine Insights reported that patients who are suffering from lupus have are deficient in vitamin D which worsens the condition. Hence regularly monitoring the level of vitamin D is essential.
A study was published in Immunologic Research in which it was reported that patients suffering from lupus have a lower level of vitamin D and a higher level of IL-17 .
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What You Need To Know About Joint Pain Is Vitamin D Good For Osteoarthritis
You should seek medical attention for any pain you experience. If the pain is caused by an infection, you should seek medical attention as soon as possible. You can take over-the-counter medications like acetaminophen or ibuprofen. If your pain is more intense, you can try heating or applying ice to the joint. Alternatively, you can also try applying heat to the affected area. To relieve the pain, you should stay away from the activities that cause you to have joint pain. A doctor can prescribe you dietary supplements, such as glucosamine, that are effective in reducing your symptoms.
If you fall or are hit on the leg and notice any swelling or deformity in your knee, you should seek medical attention. If you cant put weight on your leg, it could be a sign of a more serious ailment. If you are experiencing any of these signs and symptoms, you should consult a doctor immediately. The most important thing to do is to be patient and do not panic. The pain you experience is normal and is not related to any other health problems.
Is Vitamin D Good For Osteoarthritis Osteoarthritis is a condition that causes degeneration of the joints. People suffering from this disease will suffer from chronic pain in their joints and stiffness. They may also suffer from depression and sleep disturbances. Fortunately, there are treatments for osteoarthritis. These treatments include a change of diet and exercise. The good news is that you can get relief from your osteoarthritis symptoms today.
The Top 10 Best Supplements For Osteoarthritis
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If you are one of the millions of people who suffer from Osteoarthritis, you know how painful and debilitating the condition can be. There is no cure for Osteoarthritis, but there are a number of supplements that can help ease the symptoms. This blog post will discuss the best supplements for Osteoarthritis and how they can help improve your quality of life.
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Mri Or Magnetic Resonance Imaging
This is essentially a more sophisticated way than X-rays of taking a picture of the abnormalities that can occur due to osteoarthritis. You lie on a table that slides inside a tunnel-like area that creates a magnetic field around you. It shows more detail than X-rays, without the radiation risk, but it is more expensive as well.
Because there is no surefire test that diagnosis osteoarthritis, your doctor will use your medical history, physical exam and lab test results to look for indicators of osteoarthritis, including:
Pain, stiffness and limited movement in affected jointsBony enlargement of the affected jointsX-rays that might show formation of bone spursNarrowing of the joint space from cartilage loss shown on an X-ray
Make sure you get the proper information about your diagnosis from your doctor before you leave the office.
This includes basic information about your condition and its management.
Is Vitamin D Supplementation Necessary In Arthritis
There is a linear relationship between vitamin D deficiency and the development of arthritis.
This shows that vitamin D is absolutely essential for maintaining bone health and development.
Hence, people who are suffering from arthritis, they should make sure that they receive enough vitamin D to see a reduction in the symptoms of arthritis.
The amount of pain and disability you feel during arthritis increases with vitamin D deficiency.
Considering vitamin D helps in the absorption of calcium, people with enough vitamin D experience less pain because calcium is a natural painkiller and a relaxant.
Vitamin D has a positive effect in reducing the immune response.
What does this mean? This means that if you suffering from arthritis, then it is beneficial to increase your intake of vitamin D because it is an essential nutrient to prevent the progression of arthritis. Apart from taking supplements, it is important to consume foods that have a high content of vitamin D to attain the maximum benefits.
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Inclusion And Exclusion Criteria
Inclusion criteria to choose studies for this systematic review and meta-analysis were: RCT a nutraceutical as an intervention either as an adjunctive to standard medicine or as a monotherapy and adults who have been diagnosed with hip or knee OA sufficient data reported about mean changes for Western Ontario and McMaster Universities Arthritis index and/or Visual analogue scale at baseline and at the end of the trial in both intervention and placebo/control groups. Then selected possible clinical trials were excluded based on the exclusion criteria as follows: duplications subjects have other critical diseases such cardiovascular disease, cancer, diabetes, etc. Studies with a short period of followup review articles, semi-experimental studies without a control arm, animal studies, study protocols, letter to editors, case reports, case series, observational studies and unpublished trials.
No language limitations were applied to the search, but only studies published in English or Persian were incorporated because of translation constraints. Trials without full text and those that couldnt attain the minimum quality appraisement score were not included in this systematic review.